ArticleScientific reports2024
The potential of platelet to high-density lipoprotein cholesterol ratio (PHR) as a novel biomarker for heart failure.
Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- High-density lipoprotein antioxidant function is associated with lipid profiles and lipid-lowering therapy.Science China. Life sciences · 2026Article
- Association of platelet-to-HDL cholesterol ratio with hyperuricemia among Qatari adults: a national primary care study.Scientific reports · 2026Article
- Association of platelet to highdensity lipoprotein cholesterol ratio (PHR) with stroke and its subtypes: a large prospective cohort study.Scientific reports · 2026Article
- Association between platelet/high-density lipoprotein cholesterol ratio and incidence of coronary heart disease: insights from the UK Biobank.BMC cardiovascular disorders · 2026Article
- Association of platelet to HDL-C ratio with short-term mortality in critically ill intracerebral hemorrhage patients: a MIMIC-IV analysis.Scientific reports · 2026Article
- Development and validation of a logistic regression-based nomogram for predicting 1-year all-cause death and heart failure rehospitalization in hypertensive patients with chronic heart failure.Frontiers in cardiovascular medicine · 2026Article
- The Combined Effect of Platelet-to-HDL-Cholesterol Ratio and Glycemic Metabolism Status on the Prognosis of Patients Undergoing Percutaneous Coronary Intervention: A Large-Scale Retrospective Cohort Study.Journal of inflammation research · 2026Article
- Establishment and validation of an interpretable machine learning-based predictive model for risk of post-PCI in-hospital heart failure in AIHD patients.Frontiers in cardiovascular medicine · 2026Article
- Predictive value of gut metabolites combined with neutrophil to platelet ratio for clinical functional outcome in acute ischemic stroke treated with endovascular therapy.Frontiers in nutrition · 2026Article
- Association Between Platelet to High-Density Lipoprotein Cholesterol Ratio and Cardiometabolic Multimorbidity in Middle-Aged and Elderly Chinese Hypertensive Patients.Journal of clinical hypertension (Greenwich, Conn.) · 2025Article
- Association of platelet to high density lipoprotein cholesterol ratio with coronary lesion severity in middle aged and elderly adults.Scientific reports · 2025Article
- Article
- Association between platelet/high-density lipoprotein cholesterol ratio and blood eosinophil counts in American adults with asthma: a population-based study.Lipids in health and disease · 2025Article
- Article
- Association of platelet-to-high-density lipoprotein cholesterol ratio and its cumulative exposure with cardiovascular disease risk: a prospective cohort study in Chinese population.Frontiers in cardiovascular medicine · 2025Article
- Platelet/high-density lipoprotein cholesterol ratio as a biomarker of depression in individuals with chronic opioid use.Frontiers in psychiatry · 2025Article
- Platelet-to-high-density lipoprotein cholesterol ratio as a predictor of stroke risk: a longitudinal analysis of the China health and retirement longitudinal study.Frontiers in neurology · 2025Article
- Association between serum 25-hydroxyvitamin D concentrations and platelet to high-density lipoprotein cholesterol ratio: evidence from two population-based studies.Frontiers in nutrition · 2025Article
- Diagnostic value of platelet to high-density lipoprotein cholesterol ratio in abdominal aortic aneurysms.Frontiers in cardiovascular medicine · 2025Article
- Association of cardiovascular-kidney-metabolic syndrome with depression and all-cause mortality: a population-based observational study.Frontiers in nutrition · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Heart failure (HF) is closely linked to platelet counts and lipid levels. The platelet-to-high-density lipoprotein cholesterol ratio (PHR) is a novel marker for assessing cardiovascular disease. This study investigates the relationship between PHR and HF. We analyzed data from ten consecutive NHANES survey cycles (1998-2018), focusing on self-reported HF diagnoses with complete PHR information. PHR was calculated as platelet count divided by HDL-C (mmol/L). A multivariate logistic regression model was used to examine the association between PHR and HF, with subgroup analyses to identify potential influencing factors. RCS curve plotting and threshold effect analysis were employed to describe non-linear relationships. The study included 31,410 adults aged 20-85 years. The multivariate logistic regression indicated that individuals with the highest PHR had 82% increased likelihood of HF compared to those with the lowest PHR (OR = 1.82; 95% CI, 1.37-2.40, P < 0.001). Subgroup analyses revealed no significant interactions between PHR and specific subgroups (P > 0.05), except in those with alcohol consumption (yes/no) and BMI subgroups (P < 0.05). The association between PHR and HF was non-linear, with a notable turning point at 281.53. Elevated PHR is significantly associated with HF, suggesting it may serve as an effective clinical indicator for monitoring HF risk. Larger prospective cohort studies are needed to validate these findings and further assess the clinical utility of PHR in cardiovascular risk assessment.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.