Evidence map›Paper›PMID 39376497›Full record

ArticleiScience2024

A screen for cell envelope stress uncovers an inhibitor of prolipoprotein diacylglyceryl transferase, Lgt, in

Kenneth Rachwalski, Sean J Madden, Nicole Ritchie, Shawn French, Timsy Bhando, Adele Girgis-Gabardo, Megan Tu, Rodion Gordzevich, Rowan Ives, Amelia B Y Guo and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Kenneth RachwalskiInstitute of Infectious Disease Research, McMaster University, Hamilton, ON L8S 4L8, Canada.
Sean J MaddenInstitute of Infectious Disease Research, McMaster University, Hamilton, ON L8S 4L8, Canada.
Nicole RitchieInstitute of Infectious Disease Research, McMaster University, Hamilton, ON L8S 4L8, Canada.
Shawn FrenchInstitute of Infectious Disease Research, McMaster University, Hamilton, ON L8S 4L8, Canada.
Timsy BhandoInstitute of Infectious Disease Research, McMaster University, Hamilton, ON L8S 4L8, Canada.
Adele Girgis-GabardoInstitute of Infectious Disease Research, McMaster University, Hamilton, ON L8S 4L8, Canada.
Megan TuInstitute of Infectious Disease Research, McMaster University, Hamilton, ON L8S 4L8, Canada.
Rodion GordzevichInstitute of Infectious Disease Research, McMaster University, Hamilton, ON L8S 4L8, Canada.
Rowan IvesInstitute of Infectious Disease Research, McMaster University, Hamilton, ON L8S 4L8, Canada.
Amelia B Y GuoInstitute of Infectious Disease Research, McMaster University, Hamilton, ON L8S 4L8, Canada.
Jarrod W JohnsonInstitute of Infectious Disease Research, McMaster University, Hamilton, ON L8S 4L8, Canada.
Yiming XuDepartment of Biochemical and Cellular Pharmacology, Genentech, South San Francisco, CA, USA.
Sharookh B KapadiaDepartment of Infectious Diseases, Genentech, South San Francisco, CA, USA.
Jakob MagolanInstitute of Infectious Disease Research, McMaster University, Hamilton, ON L8S 4L8, Canada.
Eric D BrownInstitute of Infectious Disease Research, McMaster University, Hamilton, ON L8S 4L8, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The increasing prevalence of antibiotic resistance demands the discovery of antibacterial chemical scaffolds with unique mechanisms of action. Phenotypic screening approaches, such as the use of reporters for bacterial cell stress, offer promise to identify compounds while providing strong hypotheses for follow-on mechanism of action studies. From a collection of ∼1,800

Indexed as

BiotechnologyCell biologyMicrobiology

Identifiers

PMID39376497
PMCPMC11456916

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.