Evidence map›Paper›PMID 39376996›Full record

ArticleMolecular therapy. Nucleic acids2024

Inhibition of SARS-CoV-2 growth in the lungs of mice by a peptide-conjugated morpholino oligomer targeting viral RNA.

Alexandra Sakai, Gagandeep Singh, Mahsa Khoshbakht, Scott Bittner, Christiane V Löhr, Randy Diaz-Tapia, Prajakta Warang, Kris White, Luke Le Luo, Blanton Tolbert and 14 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy. Nucleic acids, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Alexandra SakaiScripps Research Institute, La Jolla, CA 92037, USA.
Gagandeep SinghDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Mahsa KhoshbakhtDepartment of Biomedical Sciences, Carlson College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331, USA.
Scott BittnerDepartment of Biomedical Sciences, Carlson College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331, USA.
Christiane V LöhrDepartment of Biomedical Sciences, Carlson College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331, USA.
Randy Diaz-TapiaDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Prajakta WarangDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Kris WhiteDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Luke Le LuoDepartment of Chemistry, Case Western Reserve University, Cleveland, OH 44106, USA.
Blanton TolbertDepartment of Chemistry, Case Western Reserve University, Cleveland, OH 44106, USA.
Mario BlancoDivision of Biology, California Institute of Technology, Pasadena, CA 91125, USA.
Amy ChowDivision of Biology, California Institute of Technology, Pasadena, CA 91125, USA.
Mitchell GuttmanDivision of Biology, California Institute of Technology, Pasadena, CA 91125, USA.
Cuiping LiNational Genomics Data Center, China National Center for Bioinformation, Beijing 100101, China.
Yiming BaoNational Genomics Data Center, China National Center for Bioinformation, Beijing 100101, China.
Joses HoGISAID @ A∗STAR Bioinformatics Institute, Singapore 138632, Singapore.
Sebastian Maurer-StrohGISAID @ A∗STAR Bioinformatics Institute, Singapore 138632, Singapore.
Arnab ChatterjeeScripps Research Institute, La Jolla, CA 92037, USA.
Sumit ChandaScripps Research Institute, La Jolla, CA 92037, USA.
Adolfo García-SastreDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Michael SchotsaertDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
John R TeijaroScripps Research Institute, La Jolla, CA 92037, USA.
Hong M MoultonDepartment of Biomedical Sciences, Carlson College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331, USA.
David A SteinDepartment of Biomedical Sciences, Carlson College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331, USA.

Funding

Combined adjuvant approaches for enhancement of SARS-CoV-2 vaccine efficacyR01AI160706 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SCHOTSAERT, MICHAEL, WONG, PAMELA TINMOI · 2022 to 2025
$2.9M
Experimental and natural SARS-CoV-2 infection of the human pancreasR01DK130425 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI HOMANN, DIRK, SCHOTSAERT, MICHAEL · 2021 to 2023
$1.3M
NIAID NIH HHS R01 AI160706NIDDK NIH HHS R01 DK130425
6 · The paper itself

Abstract

Further development of direct-acting antiviral agents against human SARS-CoV-2 infections remains a public health priority. Here, we report that an antisense peptide-conjugated morpholino oligomer (PPMO) named 5'END-2, targeting a highly conserved sequence in the 5' UTR of SARS-CoV-2 genomic RNA, potently suppressed SARS-CoV-2 growth

Indexed as

antisenseantiviralintranasal deliveryintratracheal deliveryK-18-hACE2 mouse modelMT: Oligonucleotides: Therapies and Applicationspeptide-conjugated morpholino oligomerPPMORNA virusSARS-CoV-2

Identifiers

PMID39376996
PMCPMC11456799

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.