Evidence map›Paper›PMID 39377496›Full record

ArticleClinical obesity2025

Metabolic outcomes in women 6 months and 2 years after preeclampsia versus normotensive pregnancy: A P4 study.

Yamema Esber, Megan L Gow, Sarah McLennan, Sathia Sushil, Lynne M Roberts, Mark Brown, George Mangos, Franziska Pettit, Greg K Davis, Anthony J O'Sullivan and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical obesity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yamema EsberDiscipline of Women's Health, UNSW Medicine and Health, UNSW Sydney, Sydney, New South Wales, Australia.ORCID https://orcid.org/0000-0001-8873-9026
Megan L GowDiscipline of Women's Health, UNSW Medicine and Health, UNSW Sydney, Sydney, New South Wales, Australia.ORCID https://orcid.org/0000-0002-9574-6248
Sarah McLennanDiscipline of Women's Health, UNSW Medicine and Health, UNSW Sydney, Sydney, New South Wales, Australia.
Sathia SushilDiscipline of Women's Health, UNSW Medicine and Health, UNSW Sydney, Sydney, New South Wales, Australia.
Lynne M RobertsDepartment of Women and Children's Health, St George Hospital, Sydney, New South Wales, Australia.
Mark BrownSt George and Sutherland Clinical Campus, School of Clinical Medicine, UNSW Medicine and Health, UNSW Sydney, Sydney, New South Wales, Australia.
George MangosSt George and Sutherland Clinical Campus, School of Clinical Medicine, UNSW Medicine and Health, UNSW Sydney, Sydney, New South Wales, Australia.
Franziska PettitSt George and Sutherland Clinical Campus, School of Clinical Medicine, UNSW Medicine and Health, UNSW Sydney, Sydney, New South Wales, Australia.
Greg K DavisDiscipline of Women's Health, UNSW Medicine and Health, UNSW Sydney, Sydney, New South Wales, Australia.
Anthony J O'SullivanSt George and Sutherland Clinical Campus, School of Clinical Medicine, UNSW Medicine and Health, UNSW Sydney, Sydney, New South Wales, Australia.
Amanda HenryDiscipline of Women's Health, UNSW Medicine and Health, UNSW Sydney, Sydney, New South Wales, Australia.ORCID https://orcid.org/0000-0002-7351-8922

Funding

Emeritus Professor Richard HenryNHMRC Early Career Research Fellowship APP1158876St George and Sutherland Medical Research Foundation
6 · The paper itself

Abstract

Preeclampsia is associated with an increased risk of long-term cardiometabolic disease; however, little is known regarding metabolic factors in the early postpartum years potentially contributing to these health disparities. This study aimed to compare body composition, serum biochemical parameters, energy balance and diet 6 months and 2 years after normotensive pregnancy versus preeclampsia. This is the longitudinal metabolic sub-study of the Postpartum Physiology, Psychology and Paediatric cohort study. Women were assessed 6 months and 2 years after normotensive pregnancy (n = 118) and preeclampsia (n = 47). Metabolic measures included anthropometry, body composition via bioelectrical impedance analysis, serum biochemical parameters, diet via a food recall diary, and 24-h energy expenditure using SenseWear Armbands. Two years postpartum, women after preeclampsia continued to have significantly higher weight (median 67.1 kg vs. 63.1 kg, p = .04) compared to normotensive pregnancies, in addition to higher LDL cholesterol levels (2.7 ± 0.8 mmol/L vs. 2.4 ± 0.6 mmol/L, p = .03). These women were also more likely to have an elevated HOMA-IR score ≥2.08 (44% vs. 19%, p = .01). For all women in our study, waist-to-hip ratio, percent fat mass and activity-associated energy expenditure improved overtime. However, HDL cholesterol levels deteriorated, and excess saturated fat and sodium intake persisted from 6 months postpartum. Therefore, two years after preeclampsia, women remain at greater metabolic risk than their normotensive counterparts, with greater weight, LDL cholesterol and markers of insulin resistance, potentially contributing to long-term cardiovascular morbidity and requiring early intervention.

Indexed as

Body CompositionEnergy MetabolismPre-EclampsiaAdultBlood PressureDietFemaleHumansInsulin ResistanceLongitudinal StudiesPostpartum PeriodPregnancybody compositionenergy balancemetabolic healthpostpartum healthpreeclampsia

Identifiers

PMID39377496
PMCPMC11706742

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.