Evidence map›Paper›PMID 39378318›Full record

ArticleJournal of medicinal chemistry2024

Discovery of a Series of Macrocycles as Potent Inhibitors of

Federico Riu, Larissa Alena Ruppitsch, Duc Duy Vo, Richard S Hong, Mohit Tyagi, An Matheeussen, Sarah Hendrickx, Vasanthanathan Poongavanam, Guy Caljon, Ahmad Y Sheikh and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medicinal chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Federico RiuDepartment of Chemistry - BMC, Uppsala University, 751 23 Uppsala, Sweden.
Larissa Alena RuppitschDepartment of Chemistry - BMC, Uppsala University, 751 23 Uppsala, Sweden.ORCID 0000-0003-3151-8948
Duc Duy VoDepartment of Chemistry - BMC, Uppsala University, 751 23 Uppsala, Sweden.
Richard S HongMolecular Profiling and Drug Delivery, Research & Development, AbbVie Inc., Worcester, Massachusetts 01605, United States.ORCID 0000-0002-4214-6847
Mohit TyagiDepartment of Chemistry - BMC, Uppsala University, 751 23 Uppsala, Sweden.ORCID 0000-0003-1211-629X
An MatheeussenLaboratory of Microbiology, Parasitology and Hygiene, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium.ORCID 0000-0002-7507-1634
Sarah HendrickxLaboratory of Microbiology, Parasitology and Hygiene, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium.
Vasanthanathan PoongavanamDepartment of Chemistry - BMC, Uppsala University, 751 23 Uppsala, Sweden.ORCID 0000-0002-8880-9247
Guy CaljonLaboratory of Microbiology, Parasitology and Hygiene, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium.ORCID 0000-0002-4870-3202
Ahmad Y SheikhMolecular Profiling and Drug Delivery, Research & Development, AbbVie Inc, North Chicago, Illinois 60064, United States.ORCID 0000-0002-5972-3938
Peter SjöDrugs for Neglected Diseases initiative (DNDi), 15 Chemin Camille-Vidart, 1202 Geneva, Switzerland.
Jan KihlbergDepartment of Chemistry - BMC, Uppsala University, 751 23 Uppsala, Sweden.ORCID 0000-0002-4205-6040

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Macrocycles are prominent among drugs for treatment of infectious disease, with many originating from natural products. Herein we report on the discovery of a series of macrocycles structurally related to the natural product hymenocardine. Members of this series were found to inhibit the growth of

Indexed as

Antiprotozoal AgentsLeishmania infantumMacrocyclic CompoundsPlasmodium falciparumAnimalsCrystallography, X-RayDrug DiscoveryHumansModels, MolecularParasitic Sensitivity TestsSolubilityStructure-Activity RelationshipAntiprotozoal AgentsMacrocyclic Compounds

Identifiers

PMID39378318
PMCPMC11513892

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.