Evidence map›Paper›PMID 39378334›Full record

ArticleJournal of leukocyte biology2025

B-cell interleukin 1 receptor 1 modulates the female adipose tissue immune microenvironment during aging.

Anna Carey, Louise E Pitcher, In Hwa Jang, Katie Nguyen, Stephanie Cholensky, Paul D Robbins, Christina D Camell

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of leukocyte biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Anna CareyMolecular Pharmacology and Therapeutics Graduate Program, Department of Pharmacology, University of Minnesota, 312 Church Street SE, Minneapolis, MN 55455, United States.ORCID 0000-0001-6735-6077
Louise E PitcherDepartment of Biochemistry, Molecular Biology and Biophysics, Institute on the Biology of Aging and Metabolism, University of Minnesota, 312 Church Street SE, Minneapolis, MN 55455, United States.
In Hwa JangDepartment of Biochemistry, Molecular Biology and Biophysics, Institute on the Biology of Aging and Metabolism, University of Minnesota, 312 Church Street SE, Minneapolis, MN 55455, United States.ORCID 0009-0009-9448-8433
Katie NguyenDepartment of Biochemistry, Molecular Biology and Biophysics, Institute on the Biology of Aging and Metabolism, University of Minnesota, 312 Church Street SE, Minneapolis, MN 55455, United States.
Stephanie CholenskyDepartment of Biochemistry, Molecular Biology and Biophysics, Institute on the Biology of Aging and Metabolism, University of Minnesota, 312 Church Street SE, Minneapolis, MN 55455, United States.
Paul D RobbinsMolecular Pharmacology and Therapeutics Graduate Program, Department of Pharmacology, University of Minnesota, 312 Church Street SE, Minneapolis, MN 55455, United States.ORCID 0000-0003-1068-7099
Christina D CamellMolecular Pharmacology and Therapeutics Graduate Program, Department of Pharmacology, University of Minnesota, 312 Church Street SE, Minneapolis, MN 55455, United States.ORCID 0000-0001-7847-3543

Funding

Training Grant: Functional Proteomics of AgingT32AG029796 · NIA · UNIVERSITY OF MINNESOTA · PI EDGAR A ARRIAGA, Douglas G Mashek · 2008 to 2026
$6.6M
Role of adipose tissue inflammaging and metabolic dysfunction during sepsisR01AG079913 · NIA · UNIVERSITY OF MINNESOTA · PI Christina Camell · 2023 to 2026
$2.2M
Inflammation, Lipid Metabolism and SenescenceR01AG069819 · NIA · UNIVERSITY OF MINNESOTA · PI CAMELL, CHRISTINA · 2020 to 2024
$1.9M
AFAR Grants for Junior FacultyGlenn Foundation for Medical ResearchMcKnight Land-Grant ProfessorshipMedical Discovery Team on the Biology of AgingNational Institute of Health R00AG058800NIA NIH HHS R01 AG069819NIA NIH HHS R01 AG079913NIA NIH HHS T32 AG029796
6 · The paper itself

Abstract

Myeloid cell production of interleukin-1β (IL-1β) drives inflammaging in visceral white adipose tissue (vWAT) and contributes to the expansion of interleukin-1 receptor 1 (Il1r1)-positive aged adipose B cells (AABs). AABs promote metabolic dysfunction and inflammation under inflammatory challenges. However, whether IL-1β contributes to AAB-associated inflammation during aging is unclear. Using a B-cell-specific knockout of Il1r1 (BKO mice), we characterized old vWAT in the absence of IL-1β-B-cell signaling. In addition to sex-specific metabolic improvements in females, we identified a reduction in the proportion of B cells and a sex-specific increase in the B1/B2 B-cell ratio in BKO vWAT. Using single-cell RNA sequencing of vWAT immune cells, we observed that BKO differentially affected inflammatory signaling in vWAT immune cells. These data suggest that IL-1β-B-cell signaling supports the inflammatory response in multiple cell types and provides insight into the complex microenvironment in aged vWAT.

Indexed as

Adipose TissueAgingB-LymphocytesCellular MicroenvironmentReceptors, Interleukin-1 Type IAnimalsFemaleInflammationInterleukin-1betaMaleMiceMice, Inbred C57BLMice, KnockoutSignal TransductionIL1R1 protein, mouseInterleukin-1betaReceptors, Interleukin-1 Type Iadipose tissueagingB cellsIL-1β signalingmacrophages

Identifiers

PMID39378334
PMCPMC11878995

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.