Trial reportTherapeutic advances in cardiovascular disease
Vascular-endothelial adaptations following low and high volumes of high-intensity interval training in patients after myocardial infarction.
Trial report in Therapeutic advances in cardiovascular disease. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02876952 (Effects of Combined High Intensity Aerobic Interval Training Program and Mediterranean Diet Recommendations in Post-Myocardial Infarct Patients), which is not on this map. Cited by 9 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Combined High Intensity Aerobic Interval Training Program and Mediterranean Diet Recommendations in Post-Myocardial Infarct Patients: INTERFARCT Controlled Trial
Who cites it
9 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pooled it
- Effects of high-intensity interval training on cardiopulmonary function and quality of life in patients with myocardial infarction: a meta-analysis.Frontiers in cardiovascular medicine · 2025Pooled it
- Effects of different exercise training programs on post-exercise [Formula: see text]OEuropean journal of applied physiology · 2026Trial
- Effectiveness and selection of exercise prescriptions for myocardial infarction patients: a systematic review and meta-analysis.Frontiers in cardiovascular medicine · 2026Review
- Exercise in CKM syndrome progression: a stage-specific approach to cardiovascular, metabolic, and renal health.Cardiovascular diabetology · 2025Review
- High-Intensity Interval Training as Redox Medicine: Targeting Oxidative Stress and Antioxidant Adaptations in Cardiometabolic Disease Cohorts.Antioxidants (Basel, Switzerland) · 2025Review
- High-intensity interval training in rehabilitation of patients after myocardial infarction: a rapid review of randomized trials.Postepy w kardiologii interwencyjnej = Advances in interventional cardiology · 2025Review
- Association between obstructive sleep apnea and the risk of cerebrovascular disease in COPD patients.Frontiers in medicine · 2025Article
- Carotid artery atherosclerosis, low and high volumes of high-intensity interval training in patients after myocardial infarction: the precision of measurement embarks on a precise measurement protocol.Therapeutic advances in cardiovascular diseaseArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDeterminants of coronary artery disease, such as endothelial dysfunction and oxidative stress, could be attenuated by high-intensity aerobic interval exercise training (HIIT). However, the volume of this type of training is not well established.
objectiveTo assess the impact of two volumes of HIIT, low (LV-HIIT, <10 min at high intensity) and high (HV-HIIT, >10 min at high intensity), on vascular-endothelial function in individuals after an acute myocardial infarction (AMI). MATERIALS AND
methodsClinical trial in 80 AMI patients (58.4 ± 8.3 years, 82.5% men) with three study groups: LV-HIIT (
resultsAfter the intervention, in the exercise groups, there was an increase in FMD (LV-HIIT, ↑58.8%; HV-HIIT, ↑94.1%;
conclusionIn post-AMI patients, HIIT may lead to a volume-dependent enhancement in endothelial function, attributed to a decrease in oxidative stress, with added beneficial effects in reducing vascular wall thickness. An LV-HIIT program, with less than 10 min at high intensity per session, has proven enough efficiency to initiate favorable vascular-endothelial adaptations, potentially reducing cardiovascular risk among patients with coronary artery disease.
trial registrationINTERFARCT, ClinicalTrials.gov: NCT02876952.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.