Evidence mapPaperPMID 39380341Full record

ArticleAddiction biology2024

The glucagon-like peptide-1 and other endocrine responses to alcohol ingestion in women with versus without metabolic surgery.

Mariel Molina-Castro, Neda Seyedsadjadi, Danisa Nieto, Lorenzo Leggio, Blair Rowitz, Marta Yanina Pepino

Abstract read
In one paragraph

Article in Addiction biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mariel Molina-CastroDepartment of Food Science and Human Nutrition, University of Illinois at Urbana-Champaign, Urbana-Champaign, Illinois, USA.ORCID 0009-0002-5859-8896
Neda SeyedsadjadiDepartment of Food Science and Human Nutrition, University of Illinois at Urbana-Champaign, Urbana-Champaign, Illinois, USA.
Danisa NietoDepartment of Food Science and Human Nutrition, University of Illinois at Urbana-Champaign, Urbana-Champaign, Illinois, USA.
Lorenzo LeggioClinical Psychoneuroendocrinology and Neuropsychopharmacology Section, Translational Addiction Medicine Branch, National Institute on Drug Abuse Intramural Research Program and National Institute on Alcohol Abuse and Alcoholism Division of Intramural Clinical and Biological Research, Bethesda, Maryland, USA.ORCID 0000-0001-7284-8754
Blair RowitzDivision of Nutritional Sciences, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
Marta Yanina PepinoDepartment of Food Science and Human Nutrition, University of Illinois at Urbana-Champaign, Urbana-Champaign, Illinois, USA.

Funding

PHARMACOKINETICS AND SUBJECTIVE RESPONSES TO ALCOHOL AFTER BARIATRIC SURGERYR01AA024103 · NIAAA · WASHINGTON UNIVERSITY · PI MARTA YANINA PEPINO DE GRUEV · 2016 to 2026
$3.0M
NIAAA NIH HHS R01 AA024103NIH HHS AA024103
6 · The paper itself

Abstract

Glucagon-like peptide-1 (GLP-1)-based therapies, effective in treating obesity and type 2 diabetes, hold potential for reducing alcohol-seeking behaviour. However, the understanding of how alcohol consumption affects endogenous GLP-1 responses-important for understanding GLP-1-based therapies' potential in addressing alcohol misuse-is limited, given the absence of placebo-controlled studies examining these effects. This study aimed to determine the acute effects of alcohol ingestion on GLP-1 and other peptides and evaluate whether metabolic surgery, which increases GLP-1 responses, blood alcohol concentrations (BAC) and alcohol misuse risk, influences this effect. Additionally, we assessed the acute effects of alcohol on plasma glucose and insulin concentrations. Using a placebo-controlled crossover study, we examined hormonal and glucose responses after oral alcohol consumption (0.5 g/kg of fat-free mass) versus placebo drinks in 18 women who underwent metabolic surgery <5 years ago and in 14 non-operated controls (equivalent in age, body mass index [BMI], race and alcohol consumption patterns). Women had a mean (SD) age of 41 (10) years and a BMI of 33 (5) kg/m

Indexed as

Alcohol DrinkingBlood GlucoseCross-Over StudiesGhrelinGlucagon-Like Peptide 1InsulinAdultBariatric SurgeryBlood Alcohol ContentEthanolFemaleHumansMiddle AgedPeptide YYBlood Alcohol ContentBlood GlucoseEthanolGhrelinGlucagon-Like Peptide 1InsulinPeptide YYbariatric surgeryethanolgut peptideshypoglycaemiaweight‐loss surgery

Identifiers

PMID39380341
PMCPMC11461901

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.