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ArticleNaunyn-Schmiedeberg's archives of pharmacology2025

The negative chronotropic effects of (±)-propranolol and (±)-4-NO

Denis Lima Oliveira, Vinicius Francisco Cardoso, Jose Britto-Júnior, Vivian Fuguhara, Francesco Frecentese, Rosa Sparaco, Vincenzo Santagada, Giuseppe Caliendo, André Sampaio Pupo, Edson Antunes and 1 more

Abstract read
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In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Denis Lima Oliveira *Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas (UNICAMP), 126 Tessália Vieira de Camargo St, Campinas, São Paulo, 13083-887, Brazil.
Vinicius Francisco Cardoso *Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas (UNICAMP), 126 Tessália Vieira de Camargo St, Campinas, São Paulo, 13083-887, Brazil.
Jose Britto-JúniorDepartment of Pharmacology, Faculty of Medical Sciences, State University of Campinas (UNICAMP), 126 Tessália Vieira de Camargo St, Campinas, São Paulo, 13083-887, Brazil. josebrittojr@dac.unicamp.br.
Vivian FuguharaDepartment of Pharmacology, Faculty of Medical Sciences, State University of Campinas (UNICAMP), 126 Tessália Vieira de Camargo St, Campinas, São Paulo, 13083-887, Brazil.
Francesco FrecenteseDepartment of Pharmacy, School of Medicine, University of Naples Federico II, Naples, Italy.
Rosa SparacoDepartment of Pharmacy, School of Medicine, University of Naples Federico II, Naples, Italy.
Vincenzo SantagadaDepartment of Pharmacy, School of Medicine, University of Naples Federico II, Naples, Italy.
Giuseppe CaliendoDepartment of Pharmacy, School of Medicine, University of Naples Federico II, Naples, Italy.
André Sampaio PupoDepartment of Biophysics and Pharmacology, Institute of Biosciences, São Paulo State University (UNESP), Botucatu, Brazil.
Edson AntunesDepartment of Pharmacology, Faculty of Medical Sciences, State University of Campinas (UNICAMP), 126 Tessália Vieira de Camargo St, Campinas, São Paulo, 13083-887, Brazil.
Gilberto De NucciDepartment of Pharmacology, Faculty of Medical Sciences, State University of Campinas (UNICAMP), 126 Tessália Vieira de Camargo St, Campinas, São Paulo, 13083-887, Brazil.

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 303839/2019-8Fundação de Amparo à Pesquisa do Estado de São Paulo 2017/15175-1Fundação de Amparo à Pesquisa do Estado de São Paulo 2019/16805-4Fundação de Amparo à Pesquisa do Estado de São Paulo 2021/14414-8Fundação de Amparo à Pesquisa do Estado de São Paulo 2022/07737-8
6 · The paper itself

Abstract

The positive chronotropic action induced by 6-nitrodopamine (6-ND) is selectively blocked by β

Indexed as

Adrenergic beta-AntagonistsHeart AtriaHeart RatePropranololAnimalsDose-Response Relationship, DrugIn Vitro TechniquesMaleRatsRats, WistarAdrenergic beta-AntagonistsPropranololBeta-blockerCatecholaminesL-NAMEStereoselectivity

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.