Evidence map›Paper›PMID 39382837›Full record

ArticleMolecular biology of the cell2024

Endosomal actin branching, fission, and receptor recycling require FCHSD2 recruitment by MICAL-L1.

Devin Frisby, Ajay B Murakonda, Bazella Ashraf, Kanika Dhawan, Leonardo Almeida-Souza, Naava Naslavsky, Steve Caplan

Abstract read
In one paragraph

Article in Molecular biology of the cell, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Devin FrisbyDepartment of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198.
Ajay B MurakondaDepartment of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198.
Bazella AshrafDepartment of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198.
Kanika DhawanDepartment of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198.
Leonardo Almeida-SouzaHelsinki Institute of Life Science, University of Helsinki, Helsinki 00790, Finland.
Naava NaslavskyDepartment of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198.
Steve CaplanDepartment of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198.ORCID 0000-0001-9445-4297

Funding

CHEMICAL CARCINOGENESIS &CANCER BIOLOGYT32CA009476 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Jennifer D. Black · 1988 to 2026
$6.2M
Mechanisms of membrane trafficking in endocytic and non-endocytic pathwaysR35GM144102 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Steven H Caplan · 2022 to 2026
$2.9M
NCI NIH HHS T32 CA009476NIGMS NIH HHS R35 GM144102
6 · The paper itself

Abstract

Endosome fission is required for the release of carrier vesicles and the recycling of receptors to the plasma membrane. Early events in endosome budding and fission rely on actin branching to constrict the endosomal membrane, ultimately leading to nucleotide hydrolysis and enzymatic fission. However, our current understanding of this process is limited, particularly regarding the coordination between the early and late steps of endosomal fission. Here we have identified a novel interaction between the endosomal scaffolding protein, MICAL-L1, and the human homologue of the

Indexed as

ActinsEndosomesMembrane ProteinsActin-Related Protein 2-3 ComplexAnimalsCarrier ProteinsCell MembraneCytoskeletal ProteinsDrosophila ProteinsHumansMicrofilament ProteinsMixed Function OxygenasesProtein TransportVesicular Transport ProteinsActin-Related Protein 2-3 ComplexActinsCarrier ProteinsCytoskeletal ProteinsDrosophila ProteinsEHD1 protein, humanFCHSD2 protein, humanMembrane ProteinsMICALL1 protein, humanMicrofilament ProteinsMixed Function OxygenasesVesicular Transport Proteins

Identifiers

PMID39382837
PMCPMC11617095

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.