Evidence map›Paper›PMID 39384890›Full record

ArticleScientific reports2024

Angiotensin-converting enzyme 2 activation attenuates inflammation and oxidative stress in brain death donor followed by rat lung transplantation.

Paolo Oliveira-Melo, Natalia Aparecida Nepomuceno, Liliane Moreira Ruiz, Aristides Tadeu Correia, Vanessa Sana Vilela, Karina Andrighetti de Oliveira Braga, Giovana Maria Manzuti, Deymisson Damitene Martins Feitosa, Emanuel Kennedy-Feitosa, Aizhou Wang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Paolo Oliveira-MeloDepartamento de Cardiopneumologia, Laboratório de Pesquisa em Cirurgia Torácica, Faculdade de Medicina HCFMUSP, Instituto do Coração, Universidade de Sao Paulo, Sao Paulo, SP, Brazil. paololiveiramelo@gmail.com.ORCID 0000-0003-4837-6560
Natalia Aparecida NepomucenoDepartamento de Cardiopneumologia, Laboratório de Pesquisa em Cirurgia Torácica, Faculdade de Medicina HCFMUSP, Instituto do Coração, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.
Liliane Moreira RuizDepartamento de Cardiopneumologia, Laboratório de Pesquisa em Cirurgia Torácica, Faculdade de Medicina HCFMUSP, Instituto do Coração, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.
Aristides Tadeu CorreiaDepartamento de Cardiopneumologia, Laboratório de Pesquisa em Cirurgia Torácica, Faculdade de Medicina HCFMUSP, Instituto do Coração, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.
Vanessa Sana VilelaDepartamento de Cardiopneumologia, Laboratório de Pesquisa em Cirurgia Torácica, Faculdade de Medicina HCFMUSP, Instituto do Coração, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.
Karina Andrighetti de Oliveira BragaDepartamento de Cardiopneumologia, Laboratório de Pesquisa em Cirurgia Torácica, Faculdade de Medicina HCFMUSP, Instituto do Coração, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.
Giovana Maria ManzutiDepartamento de Cardiopneumologia, Laboratório de Pesquisa em Cirurgia Torácica, Faculdade de Medicina HCFMUSP, Instituto do Coração, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.
Deymisson Damitene Martins FeitosaDepartamento de Ciências da Saúde, Laboratório de Morfofisiofarmacologia, Universidade Federal Rural do Semi-Árido, Mossoró, RN, Brazil.
Emanuel Kennedy-FeitosaDepartamento de Ciências da Saúde, Laboratório de Morfofisiofarmacologia, Universidade Federal Rural do Semi-Árido, Mossoró, RN, Brazil.
Aizhou WangToronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada.
Marcelo CypelToronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada.
Paulo Manuel Pêgo FernandesDepartamento de Cardiopneumologia, Laboratório de Pesquisa em Cirurgia Torácica, Faculdade de Medicina HCFMUSP, Instituto do Coração, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 200171/2022-4Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 88887.524323/2020-00Fundação de Amparo à Pesquisa do Estado de São Paulo 2022/07610-8
6 · The paper itself

Abstract

Brain death (BD) provides most of the donor organs destined for lung transplantation (LTx). However, the organs may be affected by inflammatory and oxidative processes. Based on this, we hypothesize that the angiotensin-converting enzyme 2 (ACE2) activation can reduce the lung injury associated with LTx. 3 h after BD induction, rats were injected with saline (BD group) or an ACE2 activator (ACE2a group; 15 mg/kg

Indexed as

Angiotensin-Converting Enzyme 2Brain DeathInflammationLung TransplantationOxidative StressAnimalsLungMalePeptidyl-Dipeptidase ARatsTissue DonorsAce2 protein, ratAngiotensin-Converting Enzyme 2Peptidyl-Dipeptidase AAngiotensin-converting enzyme 2Brain deathDonor managementIschemia–reperfusion injuryLung transplantation

Identifiers

PMID39384890
PMCPMC11464679

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.