Evidence map›Paper›PMID 39385200›Full record

ArticleJournal of neuroinflammation2024

CX3CR1

Jing Duan, Aowei Lv, Zhen Guo, Qi Liu, Chen Tian, Ying Yang, Jin Bi, Xintong Yu, Guoping Peng, Benyan Luo and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroinflammation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jing Duan *Department of Pathology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China.
Aowei Lv *Department of Neurology, Institute of Neurology of First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, China.
Zhen GuoDepartment of Pathology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China.
Qi LiuDepartment of Pathology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China.
Chen TianDepartment of Pathology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China.
Ying YangDepartment of Pathology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China.
Jin BiDepartment of Neurology, Institute of Neurology of First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, China.
Xintong YuDepartment of Neurology, Institute of Neurology of First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, China.
Guoping PengDepartment of Neurology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China.
Benyan LuoDepartment of Neurology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China.
Zhijian CaiInstitute of Immunology, Department of Orthopedics of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China.
Bin XuDepartment of Pathology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China. xubin1990@zju.edu.cn.
Ying FuDepartment of Neurology, Institute of Neurology of First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, China. fuying1995@163.com.
Jing ZhangDepartment of Pathology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China. jzhang1989@zju.edu.cn.

Funding

Key Research and Development Program of Zhejiang Province 2024C03098Leading Innovation and Entrepreneurship Team of Zhejiang Province 2020R01001National Natural Science Foundation of China 82020108012National Natural Science Foundation of China 82201560National Natural Science Foundation of China 82371250Natural Science Foundation of Zhejiang Province LY24H090006Natural Science Foundation of Zhejiang Province LZ23H090002
6 · The paper itself

Abstract

In neuroinflammation, distinguishing microglia from macrophages and identifying microglial-specific biomarkers in peripheral blood pose significant challenges. This study comprehensively profiled the extracellular vesicles (EVs) of microglia and macrophages, respectively, revealing co-expressed EVs with UCHL1 and CX3CR1 as EVs derived specifically from microglia in human blood. After extensive validation, using optimized nano flow cytometry, we evaluated plasma CX3CR1

Indexed as

BiomarkersCX3C Chemokine Receptor 1Extracellular VesiclesMicrogliaMultiple SclerosisAdultAgedCohort StudiesFemaleHumansMaleMiddle AgedUbiquitin ThiolesteraseBiomarkersCX3C Chemokine Receptor 1CX3CR1 protein, humanUbiquitin ThiolesteraseBiomarkerCX3CR1Extracellular vesiclesMicrogliaMultiple sclerosisUCHL1

Identifiers

PMID39385200
PMCPMC11465848

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.