Evidence map›Paper›PMID 39385207›Full record

ArticleAlzheimer's research & therapy2024

Relationship between hearing impairment and dementia and cognitive function: a Mendelian randomization study.

Deming Jiang, Jiahui Hou, Haitian Nan, Ailing Yue, Min Chu, Yihao Wang, Yingtao Wang, Liyong Wu

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Article in Alzheimer's research & therapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  12. Age-Related Hearing Decline and Resting-State Networks.American journal of audiology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Deming Jiang *Department of Neurology, Xuanwu Hospital, Capital Medical University, Changchun Street 45, Beijing, China.
Jiahui Hou *Department of Neurology, Xuanwu Hospital, Capital Medical University, Changchun Street 45, Beijing, China.
Haitian NanDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Changchun Street 45, Beijing, China.
Ailing YueDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Changchun Street 45, Beijing, China.
Min ChuDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Changchun Street 45, Beijing, China.
Yihao WangDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Changchun Street 45, Beijing, China.
Yingtao WangDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Changchun Street 45, Beijing, China.
Liyong WuDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Changchun Street 45, Beijing, China. wmywly@hotmail.com.

Funding

National Natural Science Foundation of China 82271464
6 · The paper itself

Abstract

backgroundThere is a substantial body of observational research indicating an association between hearing impairment and dementia, yet the causal relationship and underlying mechanisms remain uncertain. This study aims to investigate the causal relationship between hearing impairment and its subtypes with dementia and cognitive function using two-sample Mendelian randomization (MR) analysis.

methodsWe performed two-sample MR analysis to examine the causal effects of hearing impairment and its subtypes, including conductive and sensorineural hearing loss (CSHL), conductive hearing loss (CHL), sensorineural hearing loss (SHL), and sudden sensorineural hearing loss (SIHL), on six dementia phenotypes (overall dementia, Alzheimer's disease [AD], Lewy body dementia [DLB], frontotemporal dementia [FTD], Parkinson's disease dementia, and vascular dementia) and four cognitive functions. Additionally, multivariable MR (MVMR) analysis was employed to investigate potential mediating mechanisms.

resultsGenetically determined CSHL was associated with an elevated risk of DLB (odds ratio [OR] 1.69; 95% CI 1.08 to 2.63; P = 0.021) and FTD (OR 1.66; 1.04 to 2.67; P = 0.035), but not AD (P = 0.958). Genetic predisposition to CHL was found to link with increased risks of AD (OR 1.07; 1.01 to 1.14; P = 0.031). Genetically determined SHL was causally associated with an elevated risk of semantic dementia (OR 3.81; 1.09 to 13.37; P = 0.037). Genetically predicted CHL and SIHL were both causally associated with lower general cognitive performance (β -0.015 and - 0.043; P = 0.007 and 0.013) and fluid intelligence score (β -0.045 and - 0.095; P = 0.037 and 0.040). In MVMR analysis, the causal relationship between hearing impairment and dementia was mediated by loneliness, depressed mood, and brain cortical volume, particularly the medial temporal lobe, but not by aging or ischemic stroke.

conclusionOverall, the study provides evidence supporting a causal relationship between hearing impairment and increased risks of different types of dementia (including AD, FTD, and DLB), as well as poorer general cognitive function. These findings underscore the importance of addressing hearing impairment as a modifiable risk factor for dementia.

Indexed as

DementiaHearing LossMendelian Randomization AnalysisAgedCognitionFemaleHumansMaleCognitionDementiaHearing impairmentMendelian randomizationSubtype

Identifiers

PMID39385207
PMCPMC11462771

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.