Evidence map›Paper›PMID 39385515›Full record

ArticleJournal of psychopharmacology (Oxford, England)2024

Evaluation of the sedative-motor effects of novel GABAkine imidazodiazepines using quantitative observation techniques in rhesus monkeys.

Dishary Sharmin, Daniela Rüedi-Bettschen, Laís F Berro, Jemma E Cook, Jaren A Reeves-Darby, Tanya Pareek, Md Yeunus Mian, Farjana Rashid, Lalit Golani, Eliseu da Cruz Moreira-Junior and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of psychopharmacology (Oxford, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Using a rich-lean transition procedure to evaluate putative antianxiety medications.The Journal of pharmacology and experimental therapeutics · 2025
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Dishary SharminDepartment of Chemistry and Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, WI, USA.
Daniela Rüedi-BettschenDepartment of Psychiatry and Human Behavior, Center for Innovation and Discovery in Addictions, University of Mississippi Medical Center, Jackson, MS, USA.
Laís F BerroDepartment of Psychiatry and Human Behavior, Center for Innovation and Discovery in Addictions, University of Mississippi Medical Center, Jackson, MS, USA.
Jemma E CookDepartment of Psychiatry and Human Behavior, Center for Innovation and Discovery in Addictions, University of Mississippi Medical Center, Jackson, MS, USA.
Jaren A Reeves-DarbyDepartment of Psychiatry and Human Behavior, Center for Innovation and Discovery in Addictions, University of Mississippi Medical Center, Jackson, MS, USA.
Tanya PareekDepartment of Psychiatry and Human Behavior, Center for Innovation and Discovery in Addictions, University of Mississippi Medical Center, Jackson, MS, USA.ORCID 0000-0001-9133-0811
Md Yeunus MianDepartment of Chemistry and Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, WI, USA.
Farjana RashidDepartment of Chemistry and Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, WI, USA.
Lalit GolaniDepartment of Chemistry and Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, WI, USA.
Eliseu da Cruz Moreira-JuniorDepartment of Psychiatry and Human Behavior, Center for Innovation and Discovery in Addictions, University of Mississippi Medical Center, Jackson, MS, USA.
Donna M PlattDepartment of Psychiatry and Human Behavior, Center for Innovation and Discovery in Addictions, University of Mississippi Medical Center, Jackson, MS, USA.ORCID 0000-0002-8369-9544
James M CookDepartment of Chemistry and Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, WI, USA.
James K RowlettDepartment of Psychiatry and Human Behavior, Center for Innovation and Discovery in Addictions, University of Mississippi Medical Center, Jackson, MS, USA.ORCID 0000-0002-4077-5017

Funding

Role of obesity in preeclamptic pregnancy.P20GM121334 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI Pier Paolo Claudio, Babbette LaMarca · 2017 to 2026
$26.4M
ANXIOLYTIC EFFECTS AND ABUSE OF BZ RECEPTOR LIGANDSR01DA011792 · NIDA · UNIVERSITY OF MISSISSIPPI MED CTR · PI ROWLETT, JAMES K · 1998 to 2024
$7.8M
Tolerance and Physical Dependence after Chronic Benzodiazepine TreatmentR01DA043204 · NIDA · UNIVERSITY OF MISSISSIPPI MED CTR · PI JAMES K ROWLETT · 2017 to 2026
$4.3M
GABA-A receptor subtype mechanisms and the abuse-related effects of alcoholR01AA029023 · NIAAA · UNIVERSITY OF MISSISSIPPI MED CTR · PI PLATT, DONNA M · 2020 to 2024
$2.4M
Short Sleep Duration as a Predictor of Methamphetamine Intake: Role of Orexin MechanismsR01DA058666 · NIDA · UNIVERSITY OF MISSISSIPPI MED CTR · PI LAIS F BERRO · 2024 to 2026
$2.3M
Role of orexin receptors in the abuse- and sleep-related effects of methamphetamineR00DA049886 · NIDA · UNIVERSITY OF MISSISSIPPI MED CTR · PI BERRO, LAIS F · 2022 to 2024
$747k
NIAAA NIH HHS R01 AA029023NIDA NIH HHS R00 DA049886NIDA NIH HHS R01 DA011792NIDA NIH HHS R01 DA043204NIDA NIH HHS R01 DA058666NIGMS NIH HHS P20 GM121334
6 · The paper itself

Abstract

backgroundBenzodiazepines bind to γ-aminobutyric acid type A (GABA

aimsWe evaluated observable measures of sedative-motor effects and species-typical behaviors in monkeys following acute administration of novel GABAkines (positive allosteric modulators of GABA

methodsAdult female rhesus monkeys (

resultsAs with alprazolam, all GABAkines induced significant levels of mild sedation ("rest/sleep posture"). Deep sedation was observed with alprazolam, MP-III-80, and MP-III-22; motoric effects (observable ataxia) were obtained with alprazolam, KRM-II-81, and MP-III-22 only. Surprisingly, the order of potency for rest/sleep posture was significantly associated only with potency at α5GABA

conclusionsGABAkines with preferential efficacy at α2/α3GABA

Indexed as

BenzodiazepinesHypnotics and SedativesMacaca mulattaReceptors, GABA-AAllosteric RegulationAnimalsAzepinesBehavior, AnimalDose-Response Relationship, DrugFemaleImidazolesMaleMotor ActivityAzepinesBenzodiazepinesHypnotics and SedativesImidazolesReceptors, GABA-ABenzodiazepineGABAA receptorrhesus monkey (Macaca mulatta)sedative-motor

Identifiers

PMID39385515
PMCPMC12966987

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.