Evidence map›Paper›PMID 39386551›Full record

ArticlebioRxiv : the preprint server for biology2024

Adrenergic signaling gates astrocyte responsiveness to neurotransmitters and control of neuronal activity.

Kevin A Guttenplan, Isa Maxwell, Erin Santos, Luke A Borchardt, Ernesto Manzo, Leire Abalde-Atristain, Rachel D Kim, Marc R Freeman

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Kevin A GuttenplanVollum Institute, Oregon Health and Sciences University; Portland, Oregon, USA.ORCID 0000-0003-4242-4349
Isa MaxwellVollum Institute, Oregon Health and Sciences University; Portland, Oregon, USA.
Erin SantosVollum Institute, Oregon Health and Sciences University; Portland, Oregon, USA.
Luke A BorchardtVollum Institute, Oregon Health and Sciences University; Portland, Oregon, USA.
Ernesto ManzoVollum Institute, Oregon Health and Sciences University; Portland, Oregon, USA.
Leire Abalde-AtristainVollum Institute, Oregon Health and Sciences University; Portland, Oregon, USA.
Rachel D KimNeuroscience Institute, NYU Grossman School of Medicine; New York, NY., USA.ORCID 0000-0001-6361-6206
Marc R FreemanVollum Institute, Oregon Health and Sciences University; Portland, Oregon, USA.

Funding

Travel Grant PA-18-591T32NS007466 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI Kelly R Monk, Kevin Wright · 1999 to 2026
$7.0M
The Draper signaling pathway in Drosophila glial immune functionsR01NS053538 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Marc R Freeman · 2006 to 2026
$5.3M
Timeline and molecular pathways regulating astrocyte endfoot morphogenesisR01NS124146 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI Marc R Freeman, Kelly R Monk · 2021 to 2026
$3.2M
Defining genetic pathways that drive axon lossF32NS119352 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI MANZO, ERNESTO · 2020 to 2021
$122k
NINDS NIH HHS F32 NS119352NINDS NIH HHS R01 NS053538NINDS NIH HHS R01 NS124146NINDS NIH HHS T32 NS007466
6 · The paper itself

Abstract

How astrocytes regulate neuronal circuits is a fundamental, unsolved question in neurobiology. Nevertheless, few studies have explored the rules that govern when astrocytes respond to different neurotransmitters

Identifiers

PMID39386551
PMCPMC11463463

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.