ArticlebioRxiv : the preprint server for biology2024
Anatomically and Physiologically Accurate Engineered Neurovascular Unit and Blood-Brain Barrier Model Using Microvessels Isolated from Postmortem Human Brain Tissue.
Brian J O'Grady, A Scott McCall, Samuel Cullison, Daniel Chavarria, Andrew Kjar, Matthew S Schrag, Ethan S Lippmann
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
7 authors.
Brian J O'GradyDepartment of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, USA.
A Scott McCallDepartment of Pulmonary and Critical Care, Vanderbilt University Medical Center, Nashville, TN, USA.
Samuel CullisonDepartment of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, USA.
Daniel ChavarriaDepartment of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, USA.
Andrew KjarDepartment of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA.
Matthew S SchragDepartment of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.
Ethan S LippmannDepartment of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, USA.
Funding
Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Ben Ho Park · 1995 to 2026
$172.8MTranslational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MARY Kay WASHINGTON · 2002 to 2026
$29.9MShop Module CoreP30EY008126 · NEI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI David J. Calkins · 1989 to 2026
$19.6MInterdisciplinary Training Program in Lung ResearchT32HL094296 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Ray Stokes Peebles · 2008 to 2026
$6.3MPerivascular fibroblasts, vascular fibrosis, and their contributions to cerebral amyloid angiopathyRF1NS130334 · NINDS · VANDERBILT UNIVERSITY · PI LIPPMANN, ETHAN, SCHRAG, MATTHEW · 2022 to 2025
$3.9MVanderbilt Interdisciplinary Training Program in Alzheimer's DiseaseT32AG058524 · NIA · VANDERBILT UNIVERSITY · PI ANGELA L. JEFFERSON · 2018 to 2026
$3.5MiPSC-derived Neurovascular OrganoidsR01NS110665 · NINDS · VANDERBILT UNIVERSITY · PI LIPPMANN, ETHAN · 2020 to 2024
$2.5MDevelopment of a 3D neurovascular unit for in vitro modeling of subarachnoid hemorrhage and screening therapiesK99NS133399 · NINDS · VANDERBILT UNIVERSITY · PI O'GRADY, BRIAN J · 2023 to 2024
$226kNCI NIH HHS P30 CA068485NEI NIH HHS P30 EY008126NHLBI NIH HHS T32 HL094296NIA NIH HHS T32 AG058524NIDDK NIH HHS P30 DK058404NINDS NIH HHS K99 NS133399NINDS NIH HHS R01 NS110665NINDS NIH HHS RF1 NS130334
6 · The paper itselfAbstract
Brain vasculature is a complex and heterogeneous physiological structure that serves specialized roles in maintaining brain health and homeostasis. There is substantial interest in developing representative human models of the brain vasculature for drug screening and disease modeling applications. Many contemporary strategies have focused on culturing neurovascular cell types in hydrogels and microdevices, but it remains challenging to achieve anatomically relevant vascular structures that have physiologically similar function to their
Identifiers
PMID39386654
PMCPMC11463414
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