Evidence map›Paper›PMID 39386672›Full record

ArticlebioRxiv : the preprint server for biology2025

Maintenance of memory by negative-feedback of synaptic protein elimination: Modeling KIBRA-

Harel Z Shouval, Changchi Hsieh, Rafael E Flores-Obando, David Cano, Tara E Tracy, Todd C Sacktor

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Harel Z ShouvalDepartment of Neurobiology and Anatomy, University of Texas Medical School, Houston, TX 77030, USA.ORCID 0000-0003-2799-1337
Changchi HsiehDepartment of Physiology and Pharmacology, State University of New York Downstate Health Sciences University, Brooklyn, NY, 11203. USA.ORCID 0000-0003-0488-1565
Rafael E Flores-ObandoDepartment of Physiology and Pharmacology, State University of New York Downstate Health Sciences University, Brooklyn, NY, 11203. USA.
David CanoSchool of Medicine, State University of New York Downstate Health Sciences University, Brooklyn, NY, 11203. USA.
Tara E TracyBuck Institute for Research on Aging, Novato, California, 94945, USA.
Todd C SacktorDepartment of Physiology and Pharmacology, State University of New York Downstate Health Sciences University, Brooklyn, NY, 11203. USA.

Funding

PROTEIN KINASE C ISOZYMES IN HIPPOCAMPAL PLASTICITYR01MH053576 · NIMH · SUNY DOWNSTATE MEDICAL CENTER · PI SACKTOR, TODD C · 2000 to 2014
$4.9M
Molecular mechanisms of memory maintenance and dysfunction in neural circuitsR01MH115304 · NIMH · SUNY DOWNSTATE MEDICAL CENTER · PI FENTON, ANDRE ANTONIO, SACKTOR, TODD C · 2018 to 2022
$4.1M
Regulation and Neural Function of Atypical PKCR37MH057068 · NIMH · SUNY DOWNSTATE MEDICAL CENTER · PI SACKTOR, TODD C · 2011 to 2020
$4.0M
Minocycline Plus N-Acetylcysteine Improves Brain Structure and Function After Experimental Brain Injury with Clinically Useful Time WindowsR01NS108190 · NINDS · SUNY DOWNSTATE MEDICAL CENTER · PI BERGOLD, PETER J, SACKTOR, TODD C · 2019 to 2023
$2.6M
Neural coordination and discoordination in Fmr1 null miceR01NS105472 · NINDS · NEW YORK UNIVERSITY · PI FENTON, ANDRE ANTONIO · 2017 to 2021
$1.8M
NIMH NIH HHS R01 MH053576NIMH NIH HHS R01 MH115304NIMH NIH HHS R37 MH057068NINDS NIH HHS R01 NS105472NINDS NIH HHS R01 NS108190
6 · The paper itself

Abstract

Activity-dependent modifications of synaptic efficacies are a cellular substrate of learning and memory. Current theories propose that the long-term maintenance of synaptic efficacies and memory is accomplished via a positive-feedback loop at the level of production of a protein species or a protein state. Here we propose a qualitatively different theoretical framework based on negative feedback at the level of protein elimination. This theory is motivated by recent experimental findings regarding the binding of

Identifiers

PMID39386672
PMCPMC11463625

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.