Evidence map›Paper›PMID 39386707›Full record

ArticlebioRxiv : the preprint server for biology2024

Histone demethylase enzymes KDM5A and KDM5B modulate immune response by suppressing transcription of endogenous retroviral elements.

Huadong Chen, Letitia Sarah, Daniela Pucciarelli, Ying Mao, Morgan E Diolaiti, Danica Galonić Fujimori, Alan Ashworth

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Huadong ChenHelen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California.
Letitia SarahChemistry and Chemical Biology Graduate Program, University of California, San Francisco, California.
Daniela PucciarelliHelen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California.
Ying MaoHelen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California.
Morgan E DiolaitiHelen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California.
Danica Galonić FujimoriDepartment of Cellular and Molecular Pharmacology, University of California, San Francisco, California.ORCID 0000-0002-4066-9417
Alan AshworthHelen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California.

Funding

Using Networks to Seed Hierarchical Whole-cell Models of CancerU54CA209891 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI IDEKER, TREY · 2017 to 2021
$10.9M
NCI NIH HHS U54 CA209891
6 · The paper itself

Abstract

Epigenetic factors, including lysine-specific demethylases such as the KDM5 paralogs KDM5A and KDM5B have been implicated in cancer and the regulation of immune responses. Here, we performed a comprehensive multiomic study in cells lacking KDM5A or KDM5B to map changes in transcriptional regulation and chromatin organization. RNA-seq analysis revealed a significant decrease in the expression of Krüppel-associated box containing zinc finger (

Identifiers

PMID39386707
PMCPMC11463504

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.