Evidence map›Paper›PMID 39387179›Full record

ReviewExpert review of anti-infective therapy2024

Overcoming challenges in the management of recurrent urinary tract infections.

Samuel A Cornelius, Ujjaini Basu, Philippe E Zimmern, Nicole J De Nisco

Abstract readReview
In one paragraph

Review in Expert review of anti-infective therapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Samuel A CorneliusDepartment of Biological Sciences, The University of Texas at Dallas, Richardson, TX, USA.
Ujjaini BasuDepartment of Biological Sciences, The University of Texas at Dallas, Richardson, TX, USA.
Philippe E ZimmernDepartment of Urology, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Nicole J De NiscoDepartment of Biological Sciences, The University of Texas at Dallas, Richardson, TX, USA.

Funding

Defining the dynamics of urobiome structure and function in postmenopausal women and its role in recurrent UTI susceptibilityR01DK131267 · NIDDK · UNIVERSITY OF TEXAS DALLAS · PI DE NISCO, NICOLE JANELL · 2021 to 2025
$1.5M
Urovirulence and fimbrial regulation in Klebsiella quasipneumoniaeR21AI169323 · NIAID · UNIVERSITY OF TEXAS DALLAS · PI DE NISCO, NICOLE JANELL · 2023 to 2024
$450k
NIAID NIH HHS R21 AI169323NIDDK NIH HHS R01 DK131267
6 · The paper itself

Abstract

introductionUrinary tract infection (UTI) is a major global health concern. While acute UTIs can usually be effectively treated, recurrent UTIs (rUTIs) impact patients for years, causing significant morbidity and can become refractory to front-line antibiotics. AREAS COVERED: This review discusses the risk factors associated with rUTI, current rUTI treatment paradigms, prophylactic strategies, and challenges in rUTI diagnostics. We specifically discuss common risk factors for rUTI, including biological sex, age, menopause status, and diabetes mellitus. We also review recently available evidence for commonly used treatments, from oral antibiotic therapy to intravesical antimicrobials, electrofulguration of chronic cystitis, and the last-resort treatment, cystectomy. We discuss the most current literature evaluating prophylactic strategies for rUTI including long-term antibiotic prophylaxis, estrogen hormone therapy, and dietary supplements. Finally, we address the important role of UTI diagnostics in effective rUTI management and review the strengths and limitations of both current and emerging UTI diagnostic platforms as well as their ability to operate at point-of-care. EXPERT OPINION: We discuss the current challenges faced by clinicians in managing rUTI in women and the steps that should be taken so that clinicians, scientists, and patients can work together to better understand the disease and develop better strategies for its management.

Indexed as

Anti-Bacterial AgentsAntibiotic ProphylaxisRecurrenceUrinary Tract InfectionsFemaleHumansRisk FactorsSex FactorsAnti-Bacterial Agentsbiological sexdiabeteselectrofulgurationmenopause statuspoint-of-care diagnosticsradical cystectomyrecurrent urinary tract infection (rUTI)Urinary tract infection (UTI)

Identifiers

PMID39387179
PMCPMC11634670

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.