Evidence map›Paper›PMID 39387505›Full record

ArticleAnnals of medicine2024

Relationship between time to clinical remission and relapse in adults with steroid-sensitive minimal change disease: a retrospective cohort study.

Xiuyue Ye, Shenglan Gao, Kangyuan Shen, Zengzhi Xiao, Huafeng Liu, Qingjun Pan, Yongzhi Xu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xiuyue YeDepartment of Nephrology, Clinical Research Center, Guangdong Provincial Key Laboratory of Autophagy and Major Chronic Non‑Communicable Diseases, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.
Shenglan GaoDepartment of Nephrology, Clinical Research Center, Guangdong Provincial Key Laboratory of Autophagy and Major Chronic Non‑Communicable Diseases, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.
Kangyuan ShenDepartment of Nephrology, Clinical Research Center, Guangdong Provincial Key Laboratory of Autophagy and Major Chronic Non‑Communicable Diseases, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.
Zengzhi XiaoDepartment of Nephrology, Clinical Research Center, Guangdong Provincial Key Laboratory of Autophagy and Major Chronic Non‑Communicable Diseases, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.
Huafeng LiuDepartment of Nephrology, Clinical Research Center, Guangdong Provincial Key Laboratory of Autophagy and Major Chronic Non‑Communicable Diseases, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.
Qingjun PanDepartment of Nephrology, Clinical Research Center, Guangdong Provincial Key Laboratory of Autophagy and Major Chronic Non‑Communicable Diseases, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.
Yongzhi XuDepartment of Nephrology, Clinical Research Center, Guangdong Provincial Key Laboratory of Autophagy and Major Chronic Non‑Communicable Diseases, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveMinimal change disease (MCD) is a common nephrotic syndrome that is usually steroid-sensitive and has high relapse rate. The aim of this study was to investigate the relationship between time to clinical remission and recurrence after the initial steroid therapy.

methodsAmong 305 adult patients diagnosed with MCD via light and electron microscopy, sensitive to steroids, and hospitalized for nephrotic syndrome in the Department of Nephrology of the Affiliated Hospital of Guangdong Medical University in China, 88 were included in this retrospective cohort study. Cox regression analysis was performed with time to clinical remission and 24-hour urine protein quantification (24 hUTP), absolute basophil (BA) and basophil percentage (BA%) as independent variables. Independent variables with significant differences and the time to remission were used to construct a Cox regression model to exclude the influence of confounding factors. The receiver operating characteristic (ROC) curve was plotted according to the independent variable of time to clinical remission.

resultsNo significant differences were found between the relapse and non-relapse groups in terms of sex, age at onset, or prevalent hypertension. There were significant differences in time to clinical remission, 24 hUTP, BA and BA% between the relapse and non-relapse groups. The risk of recurrence was significantly higher in patients with clinical remission of 15-21, 22-28 and 29-56 days than in those who had clinical remission of 1-7 days. In addition, patients with clinical remission of >26.5 days had a significantly higher risk of recurrence than those in the other groups.

conclusionsOverall, the time of clinical remission is a potential factor for predicting the recurrence of steroid-sensitive MCD in adults.

Indexed as

Nephrosis, LipoidRecurrenceRemission InductionAdultBasophilsChinaFemaleHumansMaleMiddle AgedProportional Hazards ModelsProteinuriaRetrospective StudiesROC CurveSteroidsTime FactorsSteroidsMinimal change diseaserelapsesteroid sensitiveurine protein

Identifiers

PMID39387505
PMCPMC11469425

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.