Evidence map›Paper›PMID 39388266›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

Transcriptional repression by HDAC3 mediates T cell exclusion from

Caroline K McGuire, Ambryn S Meehan, Evan Couser, Lois Bull, Allegra C Minor, Alexandra Kuhlmann-Hogan, Susan M Kaech, Reuben J Shaw, Lillian J Eichner

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Research progress on lysine acetylation (Review).International journal of molecular medicine · 2026
    Review
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  14. Transcriptional repression by HDAC3 mediates T cell exclusion fromProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Caroline K McGuireDepartment of Biochemistry and Molecular Genetics, Northwestern University, Chicago, IL 60611.
Ambryn S Meehan *Department of Biochemistry and Molecular Genetics, Northwestern University, Chicago, IL 60611.
Evan Couser *Department of Biochemistry and Molecular Genetics, Northwestern University, Chicago, IL 60611.
Lois BullDepartment of Biochemistry and Molecular Genetics, Northwestern University, Chicago, IL 60611.
Allegra C MinorDepartment of Biochemistry and Molecular Genetics, Northwestern University, Chicago, IL 60611.
Alexandra Kuhlmann-HoganNOMIS Center for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Studies, La Jolla, CA 92037.
Susan M KaechNOMIS Center for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Studies, La Jolla, CA 92037.ORCID 0000-0003-1674-1420
Reuben J ShawMolecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla CA 92037.ORCID 0000-0002-1555-8977
Lillian J EichnerDepartment of Biochemistry and Molecular Genetics, Northwestern University, Chicago, IL 60611.ORCID 0000-0003-0225-6942

Funding

Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LEONIDAS C. PLATANIAS · 1993 to 2026
$153.9M
VIRAL MALIGNANCYP30CA023100 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jesse Nodora · 1985 to 2026
$124.9M
Viral Vector Core (VVC)P30CA014195 · NCI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI Reuben Shaw · 1985 to 2026
$82.8M
Tuberous Sclerosis-Pathway and PathogenesisP01CA120964 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI David J. Kwiatkowski · 2007 to 2026
$35.9M
Decoding And Targeting The LKB1-AMPK Signaling Pathway In CancerR35CA220538 · NCI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI Reuben Shaw · 2017 to 2026
$11.3M
CARCINOGENESIS TRAINING PROGRAMT32CA009560 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Kathleen Janee Green · 1986 to 2026
$8.4M
The HDAC3 pathway in LKB1-mutant lung cancer and senescenceK22CA251636 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI EICHNER, LILLIAN J. · 2023 to 2025
$573k
NCI NIH HHS K22 CA251636NCI NIH HHS P01 CA120964NCI NIH HHS P30 CA014195NCI NIH HHS P30 CA023100NCI NIH HHS P30 CA060553NCI NIH HHS R35 CA220538NCI NIH HHS T32 CA009560
6 · The paper itself

Abstract

Histone Deacetylase 3 (HDAC3) function in vivo is nuanced and directed in a tissue-specific fashion. The importance of HDAC3 in

Indexed as

Chemokine CXCL10Histone DeacetylasesLung NeoplasmsProto-Oncogene Proteins p21(ras)AnimalsBenzamidesCell Line, TumorGene Expression Regulation, NeoplasticHistone Deacetylase 3Histone Deacetylase InhibitorsHumansMiceMutationPyridinesPyridonesPyrimidinonesBenzamidesChemokine CXCL10CXCL10 protein, humanentinostatHistone Deacetylase 3Histone Deacetylase InhibitorsHistone DeacetylasesKRAS protein, humanProto-Oncogene Proteins p21(ras)PyridinesPyridonesPyrimidinonestrametinibHistone Deacetylase 3KRAS mutant lung cancerNF-κB p65T cell recruitmenttumor immune microenvironment

Identifiers

PMID39388266
PMCPMC11494357

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.