ArticleDiabetes care2024
Sleep Irregularity and the Incidence of Type 2 Diabetes: A Device-Based Prospective Study in Adults.
Article in Diabetes care, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Accelerometer-derived real-world sleep stages and risk of incident diseases: A UK Biobank cohort study and phenome-wide association analysis.PLoS medicine · 2026Article
- Sleep loss as a cardiometabolic risk factor: a narrative review of clinical and public health implications.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2026Review
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- Sleep and Risk for Heart Disease and Stroke.Arteriosclerosis, thrombosis, and vascular biology · 2026Review
- Time to regularize sleep regularity.Sleep · 2026Article
- Health Related Quality of Life and Sleep Regularity Among Middle-Aged to Older Adults From the Community.Journal of sleep research · 2026Article
- Fluctuations in Sleep Duration and Timing and Cardiometabolic Risk.Arteriosclerosis, thrombosis, and vascular biology · 2026Review
- From yawn to dawn: the effects of a sleep extension intervention on objective and subjective dimensions of sleep health in adults with habitual short sleep duration.Sleep advances : a journal of the Sleep Research Society · 2026Article
- Objectively measured sleep regularity, weekend recovery sleep, and the risk of incident type 2 diabetes: a prospective cohort study from the UK Biobank.International journal of surgery (London, England) · 2026Article
- Identifying sleep patterns as a synthetic signature in metabolic comorbidities using a stratified medicine approach.BMC public health · 2025Article
- Promoting healthy sleep patterns for diabetes prevention: joint effects of sleep regularity and sleep duration in a prospective Chinese cohort.BMC public health · 2025Article
- Sleep Irregularity, Circadian Disruption, and Cardiometabolic Disease Risk.Circulation research · 2025Review
- Regular sleep patterns, not just duration, critical for mental health: association of accelerometer-derived sleep regularity with incident depression and anxiety.Psychological medicine · 2025Article
- Multidimensional Sleep Health: Definitions and Implications for Cardiometabolic Health: A Scientific Statement From the American Heart Association.Circulation. Cardiovascular quality and outcomes · 2025Review
- Type 2 diabetes prediction without labs: a systems-level neural framework for risk and behavioral network reorganization.Frontiers in digital health · 2025Article
- A new method for assessing chronic insomnia: Machine learning-based fusion of TCM observation digital features.Digital healthArticle
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Authors and funding
7 authors.
Funding
Abstract
objectiveTo prospectively examine the association between device-measured sleep regularity and incidence of type 2 diabetes (T2D) in a population-based sample of adults. We also examined if meeting sleep duration recommendations attenuated or eliminated the effects of irregular sleep on T2D. RESEARCH DESIGN AND
methodsWe conducted a prospective cohort study of adults aged 40-79 years participating in the UK Biobank accelerometer substudy. Participants wore wrist-attached accelerometers for a duration of 7 days, which was used to compute the Sleep Regularity Index (SRI). Participants were categorized as irregular (SRI <71.6), moderately irregular (SRI between 71.6 and 87.3), and regular (SRI >87.3) sleepers. T2D diagnosis was obtained through self-reports and health records.
resultsWe analyzed data from 73,630 individuals observed for 8 years, without a history of T2D and without an event in the first year of follow-up. Compared with regular sleepers, irregular (hazard ratio [HR] 1.38; 95% CI 1.20-1.59) and moderately irregular sleepers (HR 1.35; 95% CI 1.19-1.53) were at higher risk of T2D incidence. Dose-response analyses treating SRI as a continuous measure showed higher T2D incidence with SRI scores <80. Meeting current sleep duration recommendations did not counteract the adverse effects of irregular (HR 1.35; 95% CI 1.09-1.66) or moderately irregular (HR 1.29; 95% CI 1.08-1.54) sleep on T2D incidence.
conclusionsModerate and high sleep irregularity were deleteriously associated with T2D risk, even in participants who slept ≥7 h per night. Future sleep interventions will need to pay more attention to consistency in bedtimes and wake-up times, in addition to sleep duration and quality.
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