Evidence map›Paper›PMID 39389123›Full record

ArticleThe Journal of allergy and clinical immunology2025

Differential T follicular helper cell phenotypes distinguish IgE-mediated milk allergy from eosinophilic esophagitis in children.

Daniel Lozano-Ojalvo, Xin Chen, Wajiha Kazmi, David Menchén-Martínez, Leticia Pérez-Rodríguez, Weslley Fernandes-Braga, Scott Tyler, Keith Benkov, Nanci Pittman, Joanne Lai and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of allergy and clinical immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Daniel Lozano-OjalvoPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY; Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY; Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY; Instituto de Investigación en Ciencias de la Alimentación, Madrid, Spain.
Xin ChenMindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY; Pediatric Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, NY.
Wajiha KazmiPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY; Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY.
David Menchén-MartínezPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY; Instituto de Investigación en Ciencias de la Alimentación, Madrid, Spain.
Leticia Pérez-RodríguezPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY.
Weslley Fernandes-BragaPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY.
Scott TylerGenetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY.
Keith BenkovPediatric Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, NY.
Nanci PittmanPediatric Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, NY.
Joanne LaiPediatric Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, NY.
Hugh A SampsonPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY; Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY.
Maria Curotto de LafaillePrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY.
David DunkinMindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY; Pediatric Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, NY.
M Cecilia BerinPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY; Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY; Department of Medicine, Feinberg School of Medicine at Northwestern University, Chicago, Ill. Electronic address: cecilia.berin@northwestern.edu.

Funding

B cell memory in human food allergyR01AI153708 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CUROTTO DE LAFAILLE, MARIA A · 2021 to 2025
$3.8M
Heterogeneity of T cell phenotype and function in food allergyR01AI151707 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BERIN, CECILIA, CUROTTO DE LAFAILLE, MARIA A · 2020 to 2024
$3.7M
NIAID NIH HHS R01 AI151707NIAID NIH HHS R01 AI153708
6 · The paper itself

Abstract

backgroundIgE-mediated food allergy and eosinophilic esophagitis (EoE) are diseases commonly triggered by milk. Milk-responsive CD4

objectiveWe sought to identify differences in CD4

methodThe total and milk-specific CD4

resultsCirculating milk-responsive T cells could be identified in active EoE and MA. An increased frequency of T

conclusionsOur studies demonstrate a dichotomy of T

Indexed as

Eosinophilic EsophagitisImmunoglobulin EMilk HypersensitivityT Follicular Helper CellsAdolescentChildChild, PreschoolCytokinesDiagnosis, DifferentialEsophagusFemaleHumansImmunophenotypingInfantMalePhenotypeCytokinesImmunoglobulin EEosinophilic esophagitisfood allergymilk allergyT follicular helperT(H)2A

Identifiers

PMID39389123
PMCPMC11895100

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.