Evidence map›Paper›PMID 39389979›Full record

ArticleNPJ systems biology and applications2024

Systems profiling reveals recurrently dysregulated cytokine signaling responses in ER+ breast cancer patients' blood.

Brian Orcutt-Jahns, Joao Rodrigues Lima Junior, Emily Lin, Russell C Rockne, Adina Matache, Sergio Branciamore, Ethan Hung, Andrei S Rodin, Peter P Lee, Aaron S Meyer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ systems biology and applications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Brian Orcutt-Jahns *Department of Bioengineering, University of California, Los Angeles (UCLA), CA, USA.ORCID 0000-0002-1436-1224
Joao Rodrigues Lima Junior *Department of Immuno-Oncology, Beckman Research Institute of the City of Hope, Duarte, CA, USA.ORCID 0000-0002-8354-8842
Emily LinDepartment of Bioengineering, University of California, Los Angeles (UCLA), CA, USA.
Russell C RockneDepartment of Computational and Quantitative Medicine, Beckman Research Institute of the City of Hope, Duarte, CA, USA.ORCID 0000-0002-1557-159X
Adina MatacheDepartment of Computational and Quantitative Medicine, Beckman Research Institute of the City of Hope, Duarte, CA, USA.
Sergio BranciamoreDepartment of Computational and Quantitative Medicine, Beckman Research Institute of the City of Hope, Duarte, CA, USA.
Ethan HungDepartment of Bioengineering, University of California, Los Angeles (UCLA), CA, USA.ORCID 0009-0008-6306-9263
Andrei S RodinDepartment of Computational and Quantitative Medicine, Beckman Research Institute of the City of Hope, Duarte, CA, USA.
Peter P LeeDepartment of Immuno-Oncology, Beckman Research Institute of the City of Hope, Duarte, CA, USA.
Aaron S MeyerDepartment of Bioengineering, University of California, Los Angeles (UCLA), CA, USA. ameyer@asmlab.org.ORCID 0000-0003-4513-1840

Funding

Transgenic Mouse FacilityP30CA033572 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI Victoria L. Seewaldt · 1985 to 2026
$86.3M
Systems Epigenomics of Persistent Bloodstream InfectionU19AI172713 · NIAID · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI ELAINE F REED · 2023 to 2026
$11.6M
Experimental-Computational Synthesis of Altered Immune Signaling in Breast CancerU01CA232216 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI LEE, PETER POON-HANG, ROCKNE, RUSSELL CHRISTIAN · 2019 to 2023
$3.0M
An integrated toolkit combining computational systems biology techniques with molecular dynamics simulations to delineate functionality of GPCRsR01LM013876 · NLM · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI RODIN, ANDREI, VAIDEHI, NAGARAJAN · 2022 to 2025
$1.5M
NCI NIH HHS P30 CA033572NCI NIH HHS U01 CA232216NIAID NIH HHS U19 AI172713NLM NIH HHS R01 LM013876U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) P30-CA033572U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) U01-CA232216U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) U19-AI172713
6 · The paper itself

Abstract

Cytokines operate in concert to maintain immune homeostasis and coordinate immune responses. In cases of ER

Indexed as

Breast NeoplasmsCytokinesSignal TransductionFemaleHumansMiddle AgedReceptors, EstrogenSystems BiologyCytokinesReceptors, Estrogen

Identifiers

PMID39389979
PMCPMC11467214

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.