Evidence map›Paper›PMID 39390412›Full record

Observational studyBMC pulmonary medicine2024

Interstitial lung abnormality in COPD is inversely associated with the comorbidity of lung cancer.

Jianrui Zheng, Jiaxi Guo, Guangdong Wang, Liang Zhang, Xinhua Yu, Dehao Liu, Yikai Lin, Rongzhou Zhang, Aiping Ma, Xiuyi Yu

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMC pulmonary medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jianrui Zheng *Department of Cardiology, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Jiaxi Guo *Department of Respiratory and Critical Medicine, School of Medicine, The First Affiliated Hospital of Xiamen University, Xiamen University, Xiamen, 361003, China.
Guangdong WangDepartment of Respiratory and Critical Medicine, School of Medicine, The First Affiliated Hospital of Xiamen University, Xiamen University, Xiamen, 361003, China.
Liang ZhangPriority Area Chronic Lung Diseases, Research Center Borstel, Borstel, Germany.
Xinhua YuPriority Area Chronic Lung Diseases, Research Center Borstel, Borstel, Germany.
Dehao LiuDepartment of Radiology, School of Medicine, The First Affiliated Hospital of Xiamen University, Xiamen University, Xiamen, China.
Yikai LinDepartment of Radiology, School of Medicine, The First Affiliated Hospital of Xiamen University, Xiamen University, Xiamen, China.
Rongzhou ZhangDepartment of Radiology, School of Medicine, The First Affiliated Hospital of Xiamen University, Xiamen University, Xiamen, China.
Aiping MaDepartment of Respiratory and Critical Medicine, School of Medicine, The First Affiliated Hospital of Xiamen University, Xiamen University, Xiamen, 361003, China. aiping.ma@xmu.edu.cn.
Xiuyi YuDepartment of Thoracic Surgery, Xiamen Key Laboratory of Thoracic tumor diagnosis and treatment, Institute of lung cancer, School of clinical Medicine, The First Affiliated Hospital of Xiamen University, Fujian Medical University, Xiamen, 361003, China. xdfyxiuyiyu@126.com.

Funding

the National Natural Science Foundation of China 81600048Xiamen Medical and Health Guidance Project 3502Z20224ZD1025Xiamen Science and Health Joint Project of Fujian Natural Science Foundation 2020J011229
6 · The paper itself

Abstract

backgroundInterstitial lung abnormality (ILA) has been recognized as a pertinent factor in the development and prognosis of various pulmonary conditions. However, its correlation with co-morbidities remains understudied. The current study endeavors to elucidate the association between ILA and both clinical features and co-morbidities in patients with chronic obstructive pulmonary disease (COPD).

methodsA retrospective cohort comprising 1131 hospitalized patients diagnosed with COPD was examined in this observational study. Patients were dichotomously classified based on the presence or absence of ILA, and subsequent analyses scrutinized disparities in demographic, clinical, and laboratory profiles, alongside co-morbid conditions, between the two subgroups.

resultsOf the 1131 COPD patients, 165 (14.6%) exhibited ILA. No statistically significant differences were discerned between COPD patients with and without ILA concerning demographic, clinical, or laboratory parameters, except for levels of circulating fibrinogen and procalcitonin. Nevertheless, a notable discrepancy emerged in the prevalence of multiple co-morbidities. Relative to COPD patients devoid of ILA, those presenting with ILA manifested a diminished prevalence of lung cancer (OR = 0.50, 95% CI: 0.30-0.83, p = 0.006), particularly of the lung adenocarcinoma (OR = 0.32, 95% CI: 0.15-0.71, p = 0.005). Additionally, the presence of ILA in COPD was positively associated with heart failure (OR = 1.75, 95% CI: 1.04-3.00, p = 0.040) and cancers other than lung cancer (OR = 2.27, 95% CI: 1.16-4.39, p = 0.012).

conclusionThese findings demonstrate that the presence of ILA is associated with co-morbidities of COPD, particularly lung cancer.

Indexed as

ComorbidityLung Diseases, InterstitialLung NeoplasmsPulmonary Disease, Chronic ObstructiveAgedAged, 80 and overFemaleHumansMaleMiddle AgedPrevalenceRetrospective StudiesComorbiditiesCOPDInterstitial lung abnormalityLung cancer

Identifiers

PMID39390412
PMCPMC11468093

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.