Evidence map›Paper›PMID 39390512›Full record

ArticleArthritis research & therapy2024

Changes and associations between synovial fluid and magnetic resonance imaging markers of osteoarthritis after high tibial osteotomy.

Jenna M Schulz, Trevor B Birmingham, Holly T Philpott, C Thomas Appleton, Hayden F Atkinson, J Robert Giffin, Frank Beier

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Article in Arthritis research & therapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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2citing papers in PubMed
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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Jenna M SchulzSchool of Physical Therapy, Faculty of Health Sciences, Western University, London, ON, Canada. jschulz2@uwo.ca.
Trevor B BirminghamSchool of Physical Therapy, Faculty of Health Sciences, Western University, London, ON, Canada.
Holly T PhilpottBone and Joint Institute, Western University, London, ON, Canada.
C Thomas AppletonBone and Joint Institute, Western University, London, ON, Canada.
Hayden F AtkinsonBone and Joint Institute, Western University, London, ON, Canada.
J Robert GiffinBone and Joint Institute, Western University, London, ON, Canada.
Frank BeierBone and Joint Institute, Western University, London, ON, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMechanobiological mechanisms of osteoarthritis (OA) are unclear. Our objectives were to explore: 1) changes in knee joint physiology using a large panel of synovial fluid biomarkers from before to one year after high tibial osteotomy (HTO) surgery, and 2) the association of changes in the synovial fluid biomarkers with the changes in MRI measures of knee effusion-synovitis and articular cartilage composition.

methodsTwenty-six patients with symptomatic knee OA and varus alignment underwent synovial fluid aspirations and 3 T MRI before and one year after medial opening wedge HTO. Cytokine and growth factor levels in synovial fluid were measured with multiplex assays. Ontology and pathway enrichment was assessed using data protein sets with gene set enrichment analysis (GSEA), and analyzed using linear mixed effects models. MRIs were analyzed for effusion-synovitis and T2 cartilage relaxation time using manual segmentations. Changes in biomarker concentrations were correlated to changes in MRI effusion-synovitis volume and articular cartilage T2 relaxation times.

resultsDecreased enrichment in Toll-like receptor and TNF-α signalling was detected one year after HTO. The leading contributors to this reduction included IL-6, TNF-α and IL-1β, whereas the highest contributors to positive enrichment were EGF, PDGF-BB and FGF-2. Effusion-synovitis volume decreased (mean [95%CI]) one year after HTO (-2811.58 [-5094.40, -528.76mm

conclusionsDecreased aberrant knee mechanical loading in patients with OA is associated with decreased biological and imaging measures of inflammation (measured in synovial fluid and on MRI) and increased anabolic processes. These exploratory findings suggest that improvement in knee loading can produce long-term (one year) improvement in joint physiology.

Indexed as

BiomarkersMagnetic Resonance ImagingOsteoarthritis, KneeOsteotomySynovial FluidTibiaAgedCartilage, ArticularCytokinesFemaleHumansKnee JointMaleMiddle AgedBiomarkersCytokinesBiomarkersEffusion-synovitisHigh tibial osteotomyInflammationMagnetic resonance imagingOsteoarthritis

Identifiers

PMID39390512
PMCPMC11465750

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.