Evidence map›Paper›PMID 39390838›Full record

ReviewCurrent medicinal chemistry2025

Anticancer Drug Discovery from Natural Compounds Targeting PI3K/AKT/mTOR Signaling Pathway.

Manuele Figueiredo da Silva, Arestides Alves Lins, Midiane Correia Gomes, Washley Phyama de Jesus Marinho, Rodrigo Santos Aquino de Araujo, Ricardo Olimpio de Moura, Peng Zhan, Igor José Dos Santos Nascimento, Edeildo Ferreira da Silva Júnior

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Manuele Figueiredo da SilvaResearch Group of Biological and Molecular Chemistry, Institute of Chemistry and Biotechnology, Federal University of Alagoas, A.C. Simões campus, Maceió, 57072-970, Brazil.
Arestides Alves LinsResearch Group of Biological and Molecular Chemistry, Institute of Chemistry and Biotechnology, Federal University of Alagoas, A.C. Simões campus, Maceió, 57072-970, Brazil.
Midiane Correia GomesResearch Group of Biological and Molecular Chemistry, Institute of Chemistry and Biotechnology, Federal University of Alagoas, A.C. Simões campus, Maceió, 57072-970, Brazil.
Washley Phyama de Jesus MarinhoDrug Development and Synthesis Laboratory, Department of Pharmacy, State University of Paraíba, Campina Grande, 58429-500, Brazil.
Rodrigo Santos Aquino de AraujoPost-Graduation Program of Pharmaceutical Sciences, Pharmacy Department, State University of Paraíba, Campina Grande, 58429-500, Brazil.
Ricardo Olimpio de MouraDrug Development and Synthesis Laboratory, Department of Pharmacy, State University of Paraíba, Campina Grande, 58429-500, Brazil.
Peng ZhanKey Laboratory of Chemical Biology, Department of Medicinal Chemistry, Ministry of Education, School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, 250012Jinan, Shandong, PR China.
Igor José Dos Santos NascimentoDrug Development and Synthesis Laboratory, Department of Pharmacy, State University of Paraíba, Campina Grande, 58429-500, Brazil.
Edeildo Ferreira da Silva JúniorResearch Group of Biological and Molecular Chemistry, Institute of Chemistry and Biotechnology, Federal University of Alagoas, A.C. Simões campus, Maceió, 57072-970, Brazil.ORCID 0000-0002-1527-4501

Funding

National Council for Scientific and Technological Development (CNPq) 150859/2023-6, 306323/2022-2
6 · The paper itself

Abstract

The term cancer is used to describe a complex pathology characterized by the uncontrollable proliferation of cells, which displays a fast metastatic spread, being a disease with difficult treatment. In this context, Phosphatidylinositol 3-kinase (PI3K) represents a promising pathway to be inhibited, aiming to develop anticancer agents, since it performs a pivotal role in regulating essential cellular processes, including cell proliferation, growth, autophagy, and apoptosis. In parallel, natural compounds can effectively represent a therapeutic strategy to fight against malignant cells. Then, compounds derived from various plant sources, such as flavonoids, terpenoids, alkaloids, coumarins, and lignans, have exhibited remarkable

Indexed as

Antineoplastic AgentsBiological ProductsDrug DiscoveryNeoplasmsPhosphoinositide-3 Kinase InhibitorsProto-Oncogene Proteins c-aktSignal TransductionTOR Serine-Threonine KinasesAnimalsCell ProliferationHumansPhosphatidylinositol 3-KinasePhosphatidylinositol 3-KinasesAntineoplastic AgentsBiological ProductsPhosphatidylinositol 3-KinasePhosphatidylinositol 3-KinasesPhosphoinositide-3 Kinase InhibitorsProto-Oncogene Proteins c-aktTOR Serine-Threonine KinasesCancer therapydrug designmolecular targetsnatural productpharmacotherapyterpenoids.

Identifiers

PMID39390838

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.