Evidence map›Paper›PMID 39391288›Full record

ArticleNature reviews. Methods primers2024

Brillouin microscopy.

Irina Kabakova, Jitao Zhang, Yuchen Xiang, Silvia Caponi, Alberto Bilenca, Jochen Guck, Giuliano Scarcelli

Abstract read
In one paragraph

Article in Nature reviews. Methods primers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. ADAMTS14 is a novel modulator of fibroblast mechanoactivation in pulmonary fibrosis.American journal of respiratory and critical care medicine · 2026
    Article
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  18. Article
  19. Review
  20. The mechanical properties ofScience advances · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Irina KabakovaSchool of Mathematical and Physical Sciences, University of Technology Sydney, Sydney, New South Wales, Australia.ORCID 0000-0002-6831-9478
Jitao ZhangDepartment of Biomedical Engineering, Wayne State University, Detroit, MI, USA.ORCID 0000-0002-6240-0371
Yuchen XiangDepartment of Metabolism, Digestion & Reproduction, Imperial College London, London, UK.
Silvia CaponiIstituto Officina dei Materiali-National Research Council (IOM-CNR)-Research Unit in Perugia, c/o Department of Physics and Geology, University of Perugia, Perugia, Italy.ORCID 0000-0002-4219-3256
Alberto BilencaBiomedical Engineering Department, Ben-Gurion University of the Negev, Be'er-Sheva, Israel.
Jochen GuckMax Planck Institute for the Science of Light, Erlangen, Germany.ORCID 0000-0002-1453-6119
Giuliano ScarcelliFischell Department of Bioengineering, University of Maryland, College Park, MD, USA.ORCID 0000-0002-1736-077X

Funding

Cornea biomechanical analysis with Brillouin microscopyR01EY028666 · NEI · UNIV OF MARYLAND, COLLEGE PARK · PI James Bradley Randleman, Giuliano Scarcelli · 2018 to 2026
$4.1M
Biomechanics of accommodationR01EY030063 · NEI · UNIVERSITY OF HOUSTON · PI LARIN, KIRILL V, MANNS, FABRICE · 2020 to 2024
$3.0M
Optically mapping tissue biomechanics during neural tube closureK25HD097288 · NICHD · WAYNE STATE UNIVERSITY · PI ZHANG, JITAO · 2019 to 2023
$562k
Stimulated Brillouin Flow Cytometry for biomechanical assessment of metastatic potentialR21CA258008 · NCI · UNIV OF MARYLAND, COLLEGE PARK · PI KONSTANTOPOULOS, KONSTANTINOS, MARTIN, STUART S · 2022 to 2023
$543k
Rapid non-invasive biomechanical imaging of neural crest cell migration in vivoR21HD112663 · NICHD · WAYNE STATE UNIVERSITY · PI ZHANG, JITAO · 2023 to 2023
$330k
NCI NIH HHS R21 CA258008NEI NIH HHS R01 EY028666NEI NIH HHS R01 EY030063NICHD NIH HHS K25 HD097288NICHD NIH HHS R21 HD112663
6 · The paper itself

Abstract

The field of Brillouin microscopy and imaging was established approximately 20 years ago, thanks to the development of non-scanning high-resolution optical spectrometers. Since then, the field has experienced rapid expansion, incorporating technologies from telecommunications, astrophotonics, multiplexed microscopy, quantum optics and machine learning. Consequently, these advancements have led to much-needed improvements in imaging speed, spectral resolution and sensitivity. The progress in Brillouin microscopy is driven by a strong demand for label-free and contact-free methods to characterize the mechanical properties of biomaterials at the cellular and subcellular scales. Understanding the local biomechanics of cells and tissues has become crucial in predicting cellular fate and tissue pathogenesis. This Primer aims to provide a comprehensive overview of the methods and applications of Brillouin microscopy. It includes key demonstrations of Brillouin microscopy and imaging that can serve as a reference for the existing research community and new adopters of this technology. The article concludes with an outlook, presenting the authors' vision for future developments in this vibrant field. The Primer also highlights specific examples where Brillouin microscopy can have a transformative impact on biology and biomedicine.

Identifiers

PMID39391288
PMCPMC11465583

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.