ArticleNature communications2024
Four Core Genotypes mice harbour a 3.2MB X-Y translocation that perturbs Tlr7 dosage.
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Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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39citing papers in PubMed
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Who cites it
39 citing papers in PubMed.
- Sex Differences and Oxidative Stress in Cardiovascular Disease.Physiology (Bethesda, Md.) · 2026Review
- Reversible, Sexually Dimorphic Sympathetic Aging: Distal Axon Withdrawal Shaped by Prepubertal Gonadal Influences.bioRxiv : the preprint server for biology · 2026Article
- Midlife Growth Hormone Receptor Ablation Extends Healthy Lifespan and Induces Sex-Specific Hepatic Transcriptional Changes at Single-Cell Resolution.Aging cell · 2026Article
- Sex-dependent mechanisms in rheumatic diseases.Nature reviews. Rheumatology · 2026Review
- Deficiency in circulating T cells in four core genotypes mice with Sry translocation.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- Peripheral and Central miRNA Signatures in Alzheimer's Disease: Tissue-Specific Variability, Sex-Associated Differences, and Implications for Blood-Based Biomarkers.International journal of molecular sciences · 2026Review
- Why males scar more: hormonal and chromosomal clues to idiopathic pulmonary fibrosis.Biology of sex differences · 2026Article
- Impact of sex chromosomes and gonad type in stress susceptibility in corticostriatal brain regions.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Placental and juvenile immune responses to maternal immune activation are differentially regulated by sex chromosomes and gonads across gestation.Journal of neuroinflammation · 2026Article
- Gonadal Sex and Sex-Chromosome Complement Interact to Affect Ethanol Consumption in Adolescent Four Core Genotypes Mice.Brain sciences · 2026Article
- Sex chromosome genes contribute to cocaine vulnerability in a strain-dependent manner.Research square · 2026Article
- Highlight on Dr. Rhonda Voskuhl: a pioneer in the exploration of sex differences in the immune response.Biology of sex differences · 2026Article
- Article
- Fetal developmental trajectories following maternal immune activation are shaped by sex chromosome-gonadal interactions.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Influenza B virus suppression of Chromosome Y-linked genes increases pulmonary virus replication and disease severity in male mice.Research square · 2026Article
- Beyond inversions and deletions: the evolutionary and functional insights from translocations, fissions, and fusions in animal genomes.Heredity · 2026Review
- New insights into sexual dimorphism in cardiometabolic health.Hormones (Athens, Greece) · 2026Review
- Sex Bias in Autoimmunity: New Findings and New Opportunities.JID innovations : skin science from molecules to population health · 2025Review
- Addressing Sex as a Biological Variable in Preclinical Models of Lung Disease: An Official American Thoracic Society Research Statement.American journal of respiratory and critical care medicine · 2025Article
- Non-homologous sequence interactions during meiosis: meiotic challenges and evolutionary opportunities.Current opinion in genetics & development · 2025Review
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Authors and funding
16 authors.
Jasper Panten *Division of Regulatory Genomics and Cancer Evolution, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Stefania Del Prete *Division of Regulatory Genomics and Cancer Evolution, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0002-1806-1819
James P Cleland *Division of Regulatory Genomics and Cancer Evolution, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Lauren M SaundersDivision of Regulatory Genomics and Cancer Evolution, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Job van RietDivision of Regulatory Genomics and Cancer Evolution, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Anja SchneiderDivision of Regulatory Genomics and Cancer Evolution, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0009-0004-9225-1145
Paul GinnoDivision of Regulatory Genomics and Cancer Evolution, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Nina SchneiderDivision of Regulatory Genomics and Cancer Evolution, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Marie-Luise KochDivision of Regulatory Genomics and Cancer Evolution, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Xuqi ChenDepartment of Integrative Biology & Physiology, University of California, Los Angeles, USA.
Moritz GerstungDivision of Artificial Intelligence in Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Oliver StegleDivision of Computational Genomics and Systems Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0002-8818-7193
Arthur P ArnoldDepartment of Integrative Biology & Physiology, University of California, Los Angeles, USA.
James M A TurnerSex Chromosome Biology Laboratory, The Francis Crick Institute, London, UK.ORCID 0000-0003-1722-7677
Edith HeardEuropean Molecular Biology Laboratory (EMBL), Heidelberg, Germany. edith.heard@embl.org.ORCID 0000-0001-8052-7117
Duncan T OdomDivision of Regulatory Genomics and Cancer Evolution, German Cancer Research Center (DKFZ), Heidelberg, Germany. d.odom@dkfz.de.ORCID 0000-0001-6201-5599
Funding
Sex Chromosome Effects on Neural DevelopmentR01NS043196 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARNOLD, ARTHUR P · 2003 to 2013
$3.4MSex differences in obesity and metabolic diseaseR01DK083561 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARNOLD, ARTHUR P, CHEN, XUQI · 2010 to 2014
$1.6MEpigenetic regulation of myocardial ischemia/reperfusion injury by X chromosomeR01HL131182 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARNOLD, ARTHUR P, EGHBALI, MANSOUREH · 2016 to 2019
$1.5MSex Differences in Dopamine SystemsR01NS045966 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARNOLD, ARTHUR P · 2003 to 2006
$1.3MFUNCTIONAL ANALYSIS OF CALCIUM STORES IN TETRAHYMENAR01GM059268 · NIGMS · UNIVERSITY OF CHICAGO · PI TURKEWITZ, AARON P · 2000 to 2003
$805kX chromosome dosage and metabolic diseaseR56DK083561 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARNOLD, ARTHUR P, REUE, KAREN · 2016 to 2016
$154kNHLBI NIH HHS R01 HL131182NIDDK NIH HHS R01 DK083561NIDDK NIH HHS R56 DK083561NIGMS NIH HHS R01 GM059268NINDS NIH HHS R01 NS043196NINDS NIH HHS R01 NS045966
Abstract
The Four Core Genotypes (FCG) is a mouse model system used to disentangle the function of sex chromosomes and hormones. We report that a copy of a 3.2 MB region of the X chromosome has translocated to the Y
Indexed as
GenotypeMice, Inbred C57BLToll-Like Receptor 7Translocation, GeneticX ChromosomeY ChromosomeAnimalsFemaleGene DosageMaleMembrane GlycoproteinsMiceMembrane GlycoproteinsTlr7 protein, mouseToll-Like Receptor 7
Identifiers
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.