Evidence map›Paper›PMID 39394539›Full record

ArticleJournal of cancer research and clinical oncology2024

SCYL1-mediated regulation of the mTORC1 signaling pathway inhibits autophagy and promotes gastric cancer metastasis.

Zihao Zhao, Jinlong Liu, Xian Gao, Zhuzheng Chen, Yilin Hu, Junjie Chen, Weijie Zang, Wanjiang Xue

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cancer research and clinical oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zihao Zhao *Department of Gastrointestinal Surgery, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, 226001, China.
Jinlong Liu *Department of Gastrointestinal Surgery, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, 226001, China.
Xian Gao *Department of Gastrointestinal Surgery, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, 226001, China.
Zhuzheng ChenDepartment of Gastrointestinal Surgery, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, 226001, China.
Yilin HuDepartment of Gastrointestinal Surgery, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, 226001, China.
Junjie ChenResearch Center of Clinical Medicine, Affiliated Hospital of Nantong University, Nantong, 226001, China.
Weijie ZangDepartment of Gastrointestinal Surgery, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, 226001, China.
Wanjiang XueDepartment of Gastrointestinal Surgery, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, 226001, China. xuewanjiang@ntu.edu.cn.

Funding

Fundation of Jiangsu Province Research Hospital YJXYY202204-ZD18National Natural Science Foundation of China 82102720Natural Science Foundation of Nantong Municipality JC2023092Natural Science Foundation of the Jiangsu Province BK20221272Postgraduate Research and Practice Innovation Program of Jiangsu Province KYCX24_3580 and SJCX24_2055Science and Technology Bureau of Nantong JC12022107
6 · The paper itself

Abstract

backgroundThe SCY1-like (SCYL) family has been reported to be closely related to cancer metastasis, but it has not been reported in gastric cancer (GC), and its specific mechanism is not clear.

methodsWe utilized databases like Deepmap, TCGA, and GEO to identify SCYL1's role in GC. Clinical samples were analyzed for SCYL1 expression and its correlation with patient prognosis. In vitro and in vivo experiments were conducted to assess SCYL1's function in GC cell migration, invasion, and autophagy.

resultsSCYL1 showed an increased expression in GC tissues, which correlated with a negative prognosis. In vitro experiments demonstrated that SCYL1 promotes GC cell migration and invasion and inhibits autophagy. GSEA indicated an inverse relationship between SCYL1 and autophagy, while a direct relationship was observed with the mTORC1 signaling pathway. Knockdown of SCYL1 enhanced autophagy, while activation of mTORC1 reversed this effect.

conclusionsSCYL1 is a significant contributor to GC progression, promoting metastasis by activating the mTORC1 signaling pathway and inhibiting autophagy. These findings suggest SCYL1 as a potential therapeutic target for GC treatment.

Indexed as

Mechanistic Target of Rapamycin Complex 1Signal TransductionStomach NeoplasmsAdaptor Proteins, Vesicular TransportAnimalsAutophagyCell Line, TumorCell MovementDNA-Binding ProteinsFemaleGene Expression Regulation, NeoplasticHumansMaleMiceMice, Inbred BALB CMice, NudeAdaptor Proteins, Vesicular TransportDNA-Binding ProteinsMechanistic Target of Rapamycin Complex 1SCYL1 protein, humanAutophagyGastric cancerMetastasismTORC1SCYL1

Identifiers

PMID39394539
PMCPMC11469978

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.