Evidence mapPaperPMID 39395208Full record

ArticleJournal of neurochemistry2025

Palmitoylation regulates norepinephrine transporter uptake, surface localization, and total expression with pathogenic implications in postural orthostatic tachycardia syndrome.

Christopher R Brown, Madhur Shetty, James D Foster

Abstract read
In one paragraph

Article in Journal of neurochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Christopher R BrownDepartment of Biomedical Sciences, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota, USA.
Madhur ShettyDepartment of Biomedical Sciences, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota, USA.
James D FosterDepartment of Biomedical Sciences, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota, USA.ORCID https://orcid.org/0000-0002-5595-0623

Funding

Research CoresP20GM103442 · NIGMS · UNIVERSITY OF NORTH DAKOTA · PI Donald A. Sens · 2012 to 2026
$53.0M
Dopamine Transporter PalmitoylationR15DA031991 · NIDA · UNIVERSITY OF NORTH DAKOTA · PI FOSTER, JAMES DARREN · 2011 to 2017
$823k
National Science Foundation 1852459NIDA NIH HHS 2R15DA031991-02A1NIDA NIH HHS R15 DA031991NIGMS NIH HHS GM103442NIGMS NIH HHS P20 GM103442
6 · The paper itself

Abstract

Postural orthostatic tachycardia syndrome (POTS) is an adrenergic signaling disorder characterized by excessive plasma norepinephrine, postural tachycardia, and syncope. The norepinephrine transporter (NET) modulates adrenergic homeostasis via the reuptake of extracellular catecholamines and is implicated in the pathogenesis of adrenergic and neurological disorders. In this study, we reveal NET is palmitoylated in male Sprague-Dawley rats and Lilly Laboratory Cell Porcine Kidney (LLC-PK

Indexed as

LipoylationNorepinephrine Plasma Membrane Transport ProteinsPostural Orthostatic Tachycardia SyndromeAnimalsHumansMalePalmitatesRatsRats, Sprague-DawleySwine2-bromopalmitateNorepinephrine Plasma Membrane Transport ProteinsPalmitatesnorepinephrine transporterpost‐translational modificationpostural orthostatic tachycardia syndromeprotein palmitoylationprotein trafficking

Identifiers

PMID39395208
PMCPMC11808474

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.