Evidence map›Paper›PMID 39395414›Full record

ArticleCell2024

Structural basis of respiratory complex adaptation to cold temperatures.

Young-Cheul Shin, Pedro Latorre-Muro, Amina Djurabekova, Oleksii Zdorevskyi, Christopher F Bennett, Nils Burger, Kangkang Song, Chen Xu, Joao A Paulo, Steven P Gygi and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
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  6. Article
  7. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Young-Cheul ShinDepartment of Chemical Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
Pedro Latorre-MuroDepartment of Cell Biology, Harvard Medical School, Boston, MA 02115, USA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA. Electronic address: pedroa_latorremuro@dfci.harvard.edu.
Amina DjurabekovaDepartment of Physics, University of Helsinki, Helsinki 00014, Finland.
Oleksii ZdorevskyiDepartment of Physics, University of Helsinki, Helsinki 00014, Finland.
Christopher F BennettDepartment of Cell Biology, Harvard Medical School, Boston, MA 02115, USA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Nils BurgerDepartment of Cell Biology, Harvard Medical School, Boston, MA 02115, USA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Kangkang SongDepartment of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA; Cryo-EM Core Facility, University of Massachusetts Medical School, Worcester, MA 01605, USA.
Chen XuDepartment of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA; Cryo-EM Core Facility, University of Massachusetts Medical School, Worcester, MA 01605, USA.
Joao A PauloDepartment of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
Steven P GygiDepartment of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
Vivek SharmaDepartment of Physics, University of Helsinki, Helsinki 00014, Finland; HiLIFE Institute of Biotechnology, University of Helsinki, Helsinki 00014, Finland.
Maofu LiaoDepartment of Chemical Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China; Institute for Biological Electron Microscopy, Southern University of Science and Technology, Shenzhen, China. Electronic address: liaomf@sustech.edu.cn.
Pere PuigserverDepartment of Cell Biology, Harvard Medical School, Boston, MA 02115, USA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA. Electronic address: pere_puigserver@dfci.harvard.edu.

Funding

Transcriptional Control of Mitochondrial Bioenergetic FunctionR01DK081418 · NIDDK · DANA-FARBER CANCER INST · PI PUIGSERVER, PERE · 2008 to 2021
$5.2M
Insulin Signaling and Metabolic Effects through CLK2 KinaseR01DK089883 · NIDDK · DANA-FARBER CANCER INST · PI PUIGSERVER, PERE · 2011 to 2020
$3.8M
Mechanisms of mitochondrial-ER communication during dietary and thermal induced stressK99DK133502 · NIDDK · DANA-FARBER CANCER INST · PI LATORRE MURO, PEDRO ANTONIO · 2023 to 2024
$180k
NIDDK NIH HHS K99 DK133502NIDDK NIH HHS R01 DK081418NIDDK NIH HHS R01 DK089883
6 · The paper itself

Abstract

In response to cold, mammals activate brown fat for respiratory-dependent thermogenesis reliant on the electron transport chain. Yet, the structural basis of respiratory complex adaptation upon cold exposure remains elusive. Herein, we combined thermoregulatory physiology and cryoelectron microscopy (cryo-EM) to study endogenous respiratory supercomplexes from mice exposed to different temperatures. A cold-induced conformation of CI:III

Indexed as

Adipose Tissue, BrownCold TemperatureCryoelectron MicroscopyThermogenesisAdaptation, PhysiologicalAnimalsBody Temperature RegulationElectron TransportMaleMiceMice, Inbred C57BLMitochondriaMitochondrial Membranesbrown adipose tissuecellular adaptationCIII(2) rotationelectron transport chainmembrane lipid remodelingrespiratory complexes

Identifiers

PMID39395414
PMCPMC11601890

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.