Evidence map›Paper›PMID 39395473›Full record

Trial reportBiological psychiatry2025

Vitamin D's Capacity to Increase Amphetamine-Induced Dopamine Release in Healthy Humans: A Clinical Translational [

Patrick D Worhunsky, Marcella M Mignosa, Jean-Dominique Gallezot, Brian Pittman, Nabeel B Nabulsi, Adam Stryjewski, Laya Jalilian-Khave, Richard Trinko, Ralph J DiLeone, Richard E Carson and 3 more

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Biological psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Patrick D WorhunskyDepartment of Psychiatry, Yale University School of Medicine, New Haven, Connecticut.
Marcella M MignosaDepartment of Psychiatry, Yale University School of Medicine, New Haven, Connecticut; The Clinical Neuroscience Research Unit, Connecticut Mental Health Center, New Haven, Connecticut.
Jean-Dominique GallezotDepartment of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, Connecticut.
Brian PittmanDepartment of Psychiatry, Yale University School of Medicine, New Haven, Connecticut.
Nabeel B NabulsiDepartment of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, Connecticut.
Adam StryjewskiDepartment of Psychiatry, Yale University School of Medicine, New Haven, Connecticut.
Laya Jalilian-KhaveDepartment of Psychiatry, Yale University School of Medicine, New Haven, Connecticut.
Richard TrinkoDepartment of Psychiatry, Yale University School of Medicine, New Haven, Connecticut; The Abraham Ribicoff Research Facilities, Connecticut Mental Health Center, New Haven, Connecticut.
Ralph J DiLeoneDepartment of Psychiatry, Yale University School of Medicine, New Haven, Connecticut; The Abraham Ribicoff Research Facilities, Connecticut Mental Health Center, New Haven, Connecticut; Department of Neuroscience, Yale University School of Medicine, New Haven, Connecticut.
Richard E CarsonDepartment of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, Connecticut.
Robert T MalisonDepartment of Psychiatry, Yale University School of Medicine, New Haven, Connecticut; The Clinical Neuroscience Research Unit, Connecticut Mental Health Center, New Haven, Connecticut.
Marc N PotenzaDepartment of Psychiatry, Yale University School of Medicine, New Haven, Connecticut; Department of Neuroscience, Yale University School of Medicine, New Haven, Connecticut; Connecticut Council on Problem Gambling, Wethersfield, Connecticut; Child Study Center, Yale University School of Medicine, New Haven, Connecticut; Connecticut Mental Health Center, New Haven, Connecticut.
Gustavo A AngaritaDepartment of Psychiatry, Yale University School of Medicine, New Haven, Connecticut; The Clinical Neuroscience Research Unit, Connecticut Mental Health Center, New Haven, Connecticut. Electronic address: gustavo.angarita@yale.edu.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Radiochemistry CoreP30DA046345 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI MACH, ROBERT H · 2019 to 2023
$9.4M
Neuroimaging Sciences Training ProgramT32DA022975 · NIDA · YALE UNIVERSITY · PI Graeme F Mason, Rajita Sinha · 2007 to 2026
$5.7M
Vitamin D Modulation of Midbrain Dopamine Function: A 11C-PHNO PET Study in Healthy HumansR01AT010508 · NCCIH · YALE UNIVERSITY · PI POTENZA, MARC N · 2019 to 2020
$1.7M
Investigation of neurofunctional reorganization in cocaine addiction using mGluR5 PET and fMRIK01DA042998 · NIDA · YALE UNIVERSITY · PI WORHUNSKY, PATRICK D · 2017 to 2021
$900k
NCATS NIH HHS UL1 TR001863NCCIH NIH HHS R01 AT010508NIDA NIH HHS K01 DA042998NIDA NIH HHS P30 DA046345NIDA NIH HHS T32 DA022975
6 · The paper itself

Abstract

backgroundDopaminergic tone and phasic release have transdiagnostic relevance. Preclinical research suggests that the active form of vitamin D, calcitriol, increases subcortical tyrosine hydroxylase, D

methodsHealthy, vitamin D-sufficient adults (N = 18, 32.8 ± 6.6 years; 33% female) participated in a randomized, double-blind, placebo-controlled within-subjects study involving 4 total scans over 2 visits consisting of same-day preamphetamine and postamphetamine (0.3 mg/kg) [

resultsFor preamphetamine scans, there was a medication × region of interest interaction (F

conclusionsResults provide translational support for vitamin D to target dopaminergic tone, with implications for clinical disorders that involve dysregulated dopamine function.

Indexed as

AmphetamineBrainCalcitriolDopamineVitamin DAdultCalciumCarbon RadioisotopesDouble-Blind MethodFemaleHumansMalePositron-Emission TomographyReceptors, Dopamine D2Young AdultAmphetamineCalcitriolCalciumCarbon RadioisotopesDopamineReceptors, Dopamine D2Vitamin DAmphetamineDopamine releaseDopamine transporterStimulantTranslational studyVitamin D

Identifiers

PMID39395473
PMCPMC11839384

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.