Evidence map›Paper›PMID 39397118›Full record

ArticleScientific reports2024

Metabolomic changes in preterminal serum samples of rhesus macaques exposed to two different lethal doses of total-body gamma-radiation.

Alana D Carpenter, Keirstyn M Empfield, Sarah A Petrus, Oluseyi O Fatanmi, Stephen Y Wise, John B Tyburski, Amrita K Cheema, Vijay K Singh

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Alana D CarpenterDivision of Radioprotectants, Department of Pharmacology and Molecular Therapeutics, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, 20814, USA.ORCID http://orcid.org/0000-0002-2108-2274
Keirstyn M EmpfieldDivision of Radioprotectants, Department of Pharmacology and Molecular Therapeutics, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, 20814, USA.ORCID http://orcid.org/0009-0002-3251-8747
Sarah A PetrusDivision of Radioprotectants, Department of Pharmacology and Molecular Therapeutics, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, 20814, USA.ORCID http://orcid.org/0000-0003-2645-7570
Oluseyi O FatanmiDivision of Radioprotectants, Department of Pharmacology and Molecular Therapeutics, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, 20814, USA.ORCID http://orcid.org/0000-0002-7942-2497
Stephen Y WiseDivision of Radioprotectants, Department of Pharmacology and Molecular Therapeutics, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, 20814, USA.ORCID http://orcid.org/0000-0002-7613-7455
John B TyburskiNelson Scientific Labs, LLC, Potomac, MD, 20854, USA.
Amrita K CheemaDepartment of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, 20057, USA.ORCID http://orcid.org/0000-0003-4877-7583
Vijay K SinghDivision of Radioprotectants, Department of Pharmacology and Molecular Therapeutics, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, 20814, USA. vijay.singh@usuhs.edu.ORCID http://orcid.org/0000-0002-6631-3849

Funding

Tissue Culture and Biobanking Shared ResourceP30CA051008 · GEORGETOWN UNIVERSITY · 1990 to 2025
$20.3M
NCI NIH HHS P30 CA051008Uniformed Services University of the Health Sciences/Armed Forces Radiobiology Research Institute AFR-B4-10978 and 12080
6 · The paper itself

Abstract

Exposure to ionizing radiation induces cellular and molecular damage leading to a cascade of events resulting in tissue and organ injury. Our study strives to characterize and validate metabolomic changes in preterminal stage (immediately prior to death) samples collected from rhesus macaques lethally irradiated with one of two different doses of radiation. Peripheral blood samples were collected pre-exposure, post-exposure, and at the preterminal stage of nonhuman primates (NHPs that did not survive exposure with 7.2 Gy or 7.6 Gy total-body radiation (LD

Indexed as

Gamma RaysMacaca mulattaMetabolomicsWhole-Body IrradiationAnimalsDose-Response Relationship, RadiationFemaleMaleMetabolome

Identifiers

PMID39397118
PMCPMC11471850

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.