Evidence map›Paper›PMID 39397269›Full record

ArticleInternational journal of experimental pathology2024

Enhanced hepatoprotective effects of empagliflozin and vitamin D dual therapy against metabolic dysfunction-associated steatohepatitis in mice by boosted modulation of metabolic, oxidative stress, and inflammatory pathways.

Wesam F Farrash, Shakir Idris, Mohamed E Elzubier, Elshiekh B A Khidir, Akhmed Aslam, Abdulrahman Mujalli, Riyad A Almaimani, Ahmad A Obaid, Mahmoud Z El-Readi, Mohammad A Alobaidy and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of experimental pathology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Wesam F FarrashDepartment of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Saudi Arabia.
Shakir IdrisDepartment of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Saudi Arabia.
Mohamed E ElzubierDepartment of Biochemistry, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia.
Elshiekh B A KhidirDepartment of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Saudi Arabia.
Akhmed AslamDepartment of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Saudi Arabia.
Abdulrahman MujalliDepartment of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Saudi Arabia.
Riyad A AlmaimaniDepartment of Biochemistry, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia.
Ahmad A ObaidDepartment of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Saudi Arabia.
Mahmoud Z El-ReadiDepartment of Biochemistry, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia.
Mohammad A AlobaidyDepartment of Anatomy, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia.ORCID 0000-0002-6911-9179
Afnan SalakaDepartment of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Saudi Arabia.
Afnan M ShakooriDepartment of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Saudi Arabia.
Alaa M SalehDepartment of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Saudi Arabia.
Faisal MinshawiDepartment of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Saudi Arabia.
Jamil A SamkariDepartment of Family and Community Medicine, Faculty of Medicine in Rabigh, King Abdulaziz University, Jeddah, Saudi Arabia.
Sallwa M AlshehreDepartment of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Saudi Arabia.
Bassem RefaatDepartment of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Saudi Arabia.ORCID 0000-0003-4267-1016

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although single treatment with sodium-glucose cotransporter-2 inhibitors (SGLT2i) or vitamin D

Indexed as

Benzhydryl CompoundsDiabetes Mellitus, ExperimentalGlucosidesLiverOxidative StressSodium-Glucose Transporter 2 InhibitorsVitamin DAnimalsDiabetes Mellitus, Type 2Diet, High-FatDrug Therapy, CombinationInflammationMaleMiceNon-alcoholic Fatty Liver DiseaseSignal TransductionBenzhydryl CompoundsempagliflozinGlucosidesSodium-Glucose Transporter 2 InhibitorsVitamin Dcholecalciferolliver fibrosisnon‐alcoholic fatty liver diseaseoxidative stressPI3K/mTOR pathwaySGLT2 inhibitor

Identifiers

PMID39397269
PMCPMC11576323

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.