Evidence map›Paper›PMID 39397430›Full record

ArticleThe Journal of international medical research2024

Reduced lipoprotein (a) in patients with severe hypertriglyceridaemia.

Erin O Jacob, Adam D McIntyre, Jian Wang, Robert A Hegele

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Article in The Journal of international medical research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Erin O JacobDepartment of Biochemistry, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
Adam D McIntyreRobarts Research Institute, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
Jian WangRobarts Research Institute, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
Robert A HegeleDepartment of Biochemistry, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.ORCID 0000-0003-2861-5325

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the relationship between plasma lipoprotein (a) (Lp[a]) and lipid profiles in patients with severe hypertriglyceridaemia (HTG).

methodsThis case-control study undertook a retrospective chart review of patients from the Lipid Genetics Clinic at London Health Sciences Centre in Ontario, Canada. Plasma Lp(a) was compared between patients with severe HTG and healthy normolipidaemic control subjects. Severe HTG was defined by plasma triglycerides (TG) ≥ 10 mmol/l. Pairwise correlations between Lp(a), TG, apolipoprotein B (apo B) and non-high-density lipoprotein cholesterol (non-HDL-C) were evaluated.

resultsThis study reviewed 4400 patients and identified 154 patients with severe HTG, which were compared with 272 control subjects. The median Lp(a) was significantly lower in patients with severe HTG compared with control subjects (5.0 versus 10.2 mg/dl, respectively). No correlation was observed between Lp(a) and TG or non-HDL-C. Lp(a) and apo B were modestly correlated in patients with severe HTG (

conclusionsPatients with severe HTG have lower plasma Lp(a) than normolipidaemic control subjects. The basis for this relationship is not immediately apparent but is hypothesis-generating and warrants further investigation.

Indexed as

HypertriglyceridemiaLipoprotein(a)TriglyceridesAdultApolipoproteins BCase-Control StudiesFemaleHumansMaleMiddle AgedRetrospective StudiesSeverity of Illness IndexApolipoproteins BLipoprotein(a)Triglyceridescomplex traithyperlipoproteinaemia type 5hypertriglyceridaemiaLipoprotein (a)lipoprotein lipasemultifactorial chylomicronaemia syndromenext-generation DNA sequencingpathogenic variant

Identifiers

PMID39397430
PMCPMC11481061

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.