Evidence map›Paper›PMID 39398242›Full record

ArticleiScience2024

A regulatory loop involving the cytochrome P450-soluble epoxide hydrolase axis and TGF-β signaling.

Xiaoming Li, Sebastian Kempf, Fredy Delgado Lagos, Ürün Ukan, Rüdiger Popp, Jiong Hu, Timo Frömel, Stefan Günther, Andreas Weigert, Ingrid Fleming

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Soluble Epoxide Hydrolase Inhibitors Improve Cornea Alkali Wound Healing.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xiaoming LiGoethe University, Institute for Vascular Signalling, Centre for Molecular Medicine, Frankfurt am Main, Germany.
Sebastian KempfGoethe University, Institute for Vascular Signalling, Centre for Molecular Medicine, Frankfurt am Main, Germany.
Fredy Delgado LagosGoethe University, Institute for Vascular Signalling, Centre for Molecular Medicine, Frankfurt am Main, Germany.
Ürün UkanGoethe University, Institute for Vascular Signalling, Centre for Molecular Medicine, Frankfurt am Main, Germany.
Rüdiger PoppGoethe University, Institute for Vascular Signalling, Centre for Molecular Medicine, Frankfurt am Main, Germany.
Jiong HuGoethe University, Institute for Vascular Signalling, Centre for Molecular Medicine, Frankfurt am Main, Germany.
Timo FrömelGoethe University, Institute for Vascular Signalling, Centre for Molecular Medicine, Frankfurt am Main, Germany.
Stefan GüntherBioinformatics and Deep Sequencing Platform, Max Planck Institute for Heart and Lung Research, 61231 Bad Nauheim, Germany.
Andreas WeigertGoethe University, Institute of Biochemistry I, Frankfurt am Main, Germany.
Ingrid FlemingGoethe University, Institute for Vascular Signalling, Centre for Molecular Medicine, Frankfurt am Main, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fatty acid metabolites, produced by cytochrome P450 enzymes and soluble epoxide hydrolase (sEH), regulate inflammation. Here, we report that the transforming growth factor β (TGF-β)-induced polarization of macrophages to a pro-resolving phenotype requires Alk5 and Smad2 activation to increase sEH expression and activity. Macrophages lacking sEH showed impaired repolarization, reduced phagocytosis, and maintained a pro-inflammatory gene expression profile. 11,12-Epoxyeicosatrienoic acid (EET) was one altered metabolite in sEH

Indexed as

BiochemistryCell biologyMolecular biologyOmicsTranscriptomics

Identifiers

PMID39398242
PMCPMC11466655

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.