ArticleAmerican journal of translational research2024
The association between vitamin C and depressive risk based on the National Health and Nutrition Examination Survey of 2017-2018 and Mendelian randomization study.
Article in American journal of translational research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Causal relationship between physical activity and common gynecologic conditions: a two-sample Mendelian randomization study.American journal of translational research · 2025Article
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6 authors.
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Abstract
objectivesThere is some debate about the link between vitamin C and depressive risk. This study utilized data from the National Health and Nutrition Examination Survey (NHANES) and Mendelian randomization (MR) methodology to investigate the association between the two.
methodsWe obtained serum vitamin C levels through laboratory data and determined the intake of vitamin C through a 24-hour dietary recall method on the first day from NHANES 2017 to 2018. Assessment of depressive risk was employed by the 9-item Patient Health Questionnaire (PHQ-9). The association between serum vitamin C levels and depressive risk was examined using logistic regression. Furthermore, the research utilized a two-sample MR methodology to investigate the potential causal connection between vitamin C and depressive risk.
resultsThree thousand four hundred and thirty-four participants aged 20+ with serum vitamin C levels and depressive risk data was included. Among the participants, 18.7% had low serum vitamin C levels and 25.2% had self-reported depressive risk. Serum vitamin C levels were associated with depressive risk [OR 1.64, (95% CI: 1.36-1.97), P < 0.01], which remained significant [OR 1.32, (95% CI: 1.08-1.61), P < 0.01] after adjustments. Distinct genetic SNPs were identified for serum vitamin C levels and depressive risk, allowing detailed analysis. No additional influences were observed between genetic variations. IVW and MR Egger analysis showed a non-causal association between vitamin C levels and depressive risk (All P > 0.05).
conclusionsOur findings of the nationally representative survey revealed a strong correlation between serum levels, intake as a supplement or medication of vitamin C and depressive risk, however, without a unidirectional causal association.
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