ArticleAmerican journal of translational research2024
Effects of herbal wet compresses on pain intensity, inflammatory factor levels, and quality of life in patients with pain.
Article in American journal of translational research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Ethanol extract fromBiotechnologia · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the pharmacological mechanisms and clinical effects of Traditional Chinese Medicine (TCM) wet compresses on pain, inflammation, and quality of life in patients with soft tissue injuries.
methodsFirst, the network pharmacology of the active ingredients from TCM wet compresses were identified using the TCMSP (Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform) database (Common monkshood mother root, Two-toothed achyranthes root, Sour orange, Garden balsam stem, Safflower, Ground beetle, Zingiber, Haichow elsholtzia herb). Relevant targets for soft tissue injuries were obtained from GeneCards, revealing 20 key therapeutic targets. Pathway clustering highlighted inflammation-related pathways. Then we conducted clinical investigation by retrospectively analyzing the data of 80 patients with soft tissue injury treated in our hospital from January 2023 to December 2023. The data from healthy subjects who had physical examination in our hospital during the same period served as the control group (n=40). According to the treatment plan, the patients were divided into study group A (n=40, external treatment with Voltaalin ointment), and study group B (n=40, treatment with TCM wet compress). Pain intensity, inflammatory factor levels, and quality of life of the patients between the two groups were compared.
resultsAnalysis of TCM wet compresses revealed 86 active ingredients and 259 intersecting targets, with key ingredients including sitogluside, beta-sitosterol, and quercetin. Key targets included IL-6, IL-1B, TNF, CXCL8, and IL10. Clinically, both patient groups showed significant reductions in pain and inflammatory markers, with greater improvements in study group B. In addition, quality of life improved notably post-treatment in study group B.
conclusionTCM wet compress patches are effective in reducing pain, modulating inflammation, and improving the quality of life in patients with soft tissue injury. These findings support TCM wet compresses as a promising alternative treatment.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.