ArticleCureus2024
Inflammatory Burden Index (IBI) and Hemoglobin, Albumin, Lymphocyte, and Platelet (HALP) Score in Alzheimer's Disease: A Retrospective Comparative Study.
Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- HALP, PIV, and SII as novel composite inflammatory indices for early detection and severity assessment of Alzheimer's disease.Frontiers in aging neuroscience · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study aimed to evaluate the differences between Alzheimer's disease (AD) patients and controls in biochemistry and peripheral hemogram parameters neutrophil, lymphocyte, monocyte, platelet, and C-reactive protein (CRP) levels, lipid profile, inflammatory burden index (IBI), and hemoglobin, albumin, lymphocyte, and platelet (HALP) score and the relationship between inflammatory and immunonutritive biomarkers and cognitive impairment in patients.
methodData from 79 patients with AD and 42 controls were included in the study. Medical data of the participants were obtained from hospital records. IBI was obtained by using the following formula: CRP × neutrophil/lymphocyte. HALP score was calculated as (hemoglobin (g/L) × albumin (g/L) × lymphocytes (/L))/platelets (/L).
resultsNeutrophil count (p=0.003, effect size=0.60), CRP level (p<0.001, effect size=0.87), and IBI (p<0.001, effect size=0.93) were significantly higher in AD patients compared to the control group; hemoglobin (p<0.001, effect size=1.03), lymphocyte count (p<0.001, effect size=0.78), albumin level (p<0.001, effect size=1.31), and HALP score (p<0.001, effect size=0.85) were lower. According to the Standardized Mini Mental Test (SMMT) score, neutrophil count (p=0.001), CRP (p<0.001), and IBI (p<0.001) were significantly higher and lymphocyte count (p=0.001) and HALP score (p<0.001) were lower in the group with severe cognitive impairment. Albumin levels were highest in the group with mild cognitive impairment. In the patient group, there was a moderately significant negative relationship between SMMT score and age (p<0.001, r=-0.437), neutrophil count (p=0.033, r=-0.240), CRP (p<0.001, r=-0.451), and IBI (p<0.001, r=-0.538). Lymphocyte count (p<0.001, r=0.412), high-density lipoprotein (HDL) (p=0.049, r=0.223), albumin levels (p=0.001, r=0.357), and HALP score (p<0.001, r=0.486) were moderately positively associated with SMMT score. Age (β=-0.437, p<0.001), HALP score (β=0.403, p<0.001), and IBI (β=-0.322, p=0.004) were found to be predictors for the severity of cognitive impairment.
conclusionOur results revealed that inflammation and immunonutritive status play an important role in the pathogenesis of AD. Novel inflammatory and immunonutritive biomarkers, and IBI and HALP score may be promising clinical tools that may pave the way for more personalized treatment strategies and interventions for patients.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.