In one paragraphArticle in Research square, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
18 authors.
Riccardo VernuccioG5 Structural Biology of Infectious Diseases, Institut Pasteur, Université Paris Cité, Paris, France.ORCID 0009-0009-8319-0922 Alejandro Martínez LeónTheoretical Physics and Center for Biophysics, Saarland University, 66123, Saarbrücken, Germany.ORCID 0009-0005-6162-7303 Chetan S PoojariTheoretical Physics and Center for Biophysics, Saarland University, 66123, Saarbrücken, Germany.ORCID 0000-0001-6575-221X Julian BuchrieserVirus & Immunity Unit, Institut Pasteur, Université Paris Cité, CNRS, UMR 3569, Paris, France.ORCID 0000-0003-4790-7577 Christopher SelverianDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA.ORCID 0000-0002-1047-4336 Yakin JaletaDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA.
Annalisa MeolaG5 Structural Biology of Infectious Diseases, Institut Pasteur, Université Paris Cité, Paris, France.
Florence Guivel-BenhassineTheoretical Physics and Center for Biophysics, Saarland University, 66123, Saarbrücken, Germany.
Françoise PorrotTheoretical Physics and Center for Biophysics, Saarland University, 66123, Saarbrücken, Germany.ORCID 0000-0001-8995-3614 Ahmed HaouzCristallography Platform-C2RT, UMR3528, Institut Pasteur, CNRS, Université de Paris, Paris, France.ORCID 0000-0003-1196-1635 Maelenn ChevreuilPlate-forme de Biophysique Moleculaire-C2RT, Institut Pasteur, CNRS UMR 3528, Université Paris Cité, Paris, France.
Bertrand RaynalPlate-forme de Biophysique Moleculaire-C2RT, Institut Pasteur, CNRS UMR 3528, Université Paris Cité, Paris, France.ORCID 0000-0001-5634-0408 Jason MercerInstitute of Microbiology and Infection, School of Biosciences, University of Birmingham, Birmingham, UK.
Etienne Simon-LoriereG5 Evolutionary Genomics of RNA Viruses, Institut Pasteur, Université Paris Cité, Paris, France.ORCID 0000-0001-8420-7743 Kartik ChandranDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA.ORCID 0000-0003-0232-7077 Olivier SchwartzVirus & Immunity Unit, Institut Pasteur, Université Paris Cité, CNRS, UMR 3569, Paris, France.ORCID 0000-0002-0729-1475 Jochen S HubTheoretical Physics and Center for Biophysics, Saarland University, 66123, Saarbrücken, Germany.
Pablo Guardado-CalvoG5 Structural Biology of Infectious Diseases, Institut Pasteur, Université Paris Cité, Paris, France.
Funding
Inter-regional study of transmission, adaptation and pathogenesis of viruses with pandemic potential in Southeast Asia and West/Central AfricaU01AI151758 · NIAID · INSTITUT PASTEUR · PI SAKUNTABHAI, ANAVAJ, SIMON-LORIERE, ETIENNE · 2020 to 2024
$6.7MNIAID NIH HHS U01 AI151758
6 · The paper itselfAbstract
Mpox is a zoonotic disease endemic in central and west Africa. However, since 2022, human-adapted mpox virus (MPXV) strains are causing large outbreaks spreading outside these regions, leading the World Health Organization to declare public health emergency twice. Tecovirimat, the most widely used drug to treat these infections, blocks viral egress through a poorly understood mechanism. Tecovirimat-resistant strains, all with mutations in the viral phospholipase F13, pose public health concerns. Herein, we report the structure of an F13 homodimer, both alone and in complex with tecovirimat. We demonstrate that tecovirimat acts as a molecular glue, inducing the dimerization of the phospholipase. F13 escape mutations in MPXV clinical isolates are at the dimer interface and prevent drug-induced dimerization in solution and cells. These findings, which decipher tecovirimat's mode of action, will allow better monitoring of poxvirus outbreaks and pave the way for developing more potent and resilient therapeutics.
Identifiers
PMID39399667
PMCPMC11469519
What Socratic holds
Textmetadata
LicenceCC BY
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