Cellular mechanisms of synchronized rhythmic burst generation in the ventromedial hypothalamus.

Kamon Iigaya, Hiroshi Onimaru, Keiko Ikeda, Makito Iizuka, Masahiko Izumizaki

Abstract read

In one paragraph

Article in Pflugers Archiv : European journal of physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Discovery of Personalized Treatment for Immuno-Metabolic Depression-Focus on 11beta Hydroxysteroid Dehydrogenase Type 2 (11betaHSD2) and Toll-like Receptor 4 (TLR4) Inhibition with Enoxolone.Pharmaceuticals (Basel, Switzerland) · 2025
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kamon IigayaDepartment of Physiology, Showa University School of Medicine, Tokyo, 142-8555, Japan.

Hiroshi OnimaruDepartment of Physiology, Showa University School of Medicine, Tokyo, 142-8555, Japan. oni@med.showa-u.ac.jp.

Keiko IkedaDepartment of Oral Physiology, Showa University School of Dentistry, Tokyo, 142-8555, Japan.

Makito IizukaDepartment of Physiology, Showa University School of Medicine, Tokyo, 142-8555, Japan.

Masahiko IzumizakiDepartment of Physiology, Showa University School of Medicine, Tokyo, 142-8555, Japan.

Funding

Japan Society for the Promotion of Science 19K06946

6 · The paper itself

Abstract

The ventromedial hypothalamus (VMH) plays an important role in feeding behavior and control of the sympathetic nervous system (SNS). The VMH includes a group of neurons that exhibit strong synchronized rhythmic burst firing (so-called VMH oscillation). This VMH oscillation is glucose inhibited, responsive to feeding-related peptides, and is functionally coupled to outputs of the SNS. However, the details of its rhythm generation and synchronization mechanisms are unknown. In the present study, we investigated cellular mechanisms of VMH oscillation by means of electrophysiological recordings and calcium imaging in juvenile rat slice preparations including the VMH. In the electrophysiological study, we performed membrane potential recording from neurons in the vicinity of pipettes for field potential recording. We found that the rhythmic bursts in the VMH were preserved in low Ca

Indexed as

Action PotentialsNeuronsAnimalsCalciumCarbenoxoloneGap JunctionsMaleMembrane PotentialsRatsRats, WistarRiluzoleSodium Channel BlockersVentromedial Hypothalamic NucleusCalciumCarbenoxoloneRiluzoleSodium Channel BlockersGap junctionOscillationPersistent sodium channelsVentromedial hypothalamus

Identifiers

PMID39400580

DOI10.3390/biom10111578

What Socratic holds

Textmetadata

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.