Evidence map›Paper›PMID 39400646›Full record

ArticleJournal of assisted reproduction and genetics2024

CircDDX21 alleviates trophoblast dysfunction and Treg differentiation in recurrent spontaneous abortion via miR-520a-5p/ FOXP3/PD-L1 axis.

Biao Duan, Qing Feng, Li Li, Jiangfang Huang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of assisted reproduction and genetics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Biao DuanReproductive Medicine Department, The Affiliated Ganzhou Hospital of Nanchang University, No. 16 Meiguan Avenue, Zhanggong District, Ganzhou, 341000, Jiangxi Province, China. duanbiao707@163.com.ORCID http://orcid.org/0009-0007-3730-1762
Qing FengReproductive Medicine Department, The Affiliated Ganzhou Hospital of Nanchang University, No. 16 Meiguan Avenue, Zhanggong District, Ganzhou, 341000, Jiangxi Province, China.
Li LiReproductive Medicine Department, The Affiliated Ganzhou Hospital of Nanchang University, No. 16 Meiguan Avenue, Zhanggong District, Ganzhou, 341000, Jiangxi Province, China.
Jiangfang HuangReproductive Medicine Department, The Affiliated Ganzhou Hospital of Nanchang University, No. 16 Meiguan Avenue, Zhanggong District, Ganzhou, 341000, Jiangxi Province, China.

Funding

The National Natural Science Foundation of China 82260310The Science and Technology Plan Project of Jiangxi Provincial Health Commission 202210092
6 · The paper itself

Abstract

backgroundRecurrent spontaneous abortion (RSA) is a common complication during pregnancy, which is a burden to patients both physically and mentally. Circular RNAs (circRNAs) play important roles in RSA. However, the roles of circDDX21 in RSA development remain unknown.

methodsDecidual samples were harvested from healthy pregnant women and RSA patients. In HTR-8/SVneo and Bewo trophoblast cells, proliferation and migration were analyzed by cell counting kit-8 (CCK-8)/5-ethynyl-2'-deoxyuridine (EdU) staining and transwell/wound healing assays, respectively. CD4

resultsCircDDX21 and Forkhead box P3 (FOXP3) decreased, while miR-520a-5p increased in the decidual tissues of RSA patients. CircDDX21 overexpression promoted trophoblast proliferation and migration, and facilitated CD4

conclusionCircDDX21 ameliorated trophoblast dysfunction and Treg differentiation in RSA via miR-520a-5p/FOXP3/PD-L1 axis.

Indexed as

Abortion, HabitualCell DifferentiationForkhead Transcription FactorsMicroRNAsRNA, CircularT-Lymphocytes, RegulatoryTrophoblastsAdultB7-H1 AntigenCell ProliferationFemaleHumansPregnancyB7-H1 AntigenCD274 protein, humanForkhead Transcription FactorsFOXP3 protein, humanMicroRNAsMIRN520 microRNA, humanRNA, CircularCircDDX21FOXP3MiR-520a-5pRecurrent spontaneous abortionTrophoblast

Identifiers

PMID39400646
PMCPMC11706825

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.