Evidence map›Paper›PMID 39400901›Full record

ArticleDoklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections2024

The Role of BDNF in the Antidepressant Effects of Electroconvulsive Therapy.

V M Ushakova, E A Zubkov, A Yu Morozova, K A Pavlov, Ya A Zorkina, O V Abramova, A G Ochneva, O I Gurina, K Sh Tarkovskaya, A N Inozemtsev and 1 more

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Article in Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

V M UshakovaDepartment of Basic and Applied Neurobiology, Serbsky National Medical Research Center of Psychiatry and Narcology of the RF Ministry of Public Health, Moscow, Russia. ushakovavm@yandex.ru.
E A ZubkovDepartment of Basic and Applied Neurobiology, Serbsky National Medical Research Center of Psychiatry and Narcology of the RF Ministry of Public Health, Moscow, Russia.
A Yu MorozovaDepartment of Basic and Applied Neurobiology, Serbsky National Medical Research Center of Psychiatry and Narcology of the RF Ministry of Public Health, Moscow, Russia.
K A PavlovDepartment of Basic and Applied Neurobiology, Serbsky National Medical Research Center of Psychiatry and Narcology of the RF Ministry of Public Health, Moscow, Russia.
Ya A ZorkinaDepartment of Basic and Applied Neurobiology, Serbsky National Medical Research Center of Psychiatry and Narcology of the RF Ministry of Public Health, Moscow, Russia.
O V AbramovaDepartment of Basic and Applied Neurobiology, Serbsky National Medical Research Center of Psychiatry and Narcology of the RF Ministry of Public Health, Moscow, Russia.
A G OchnevaDepartment of Basic and Applied Neurobiology, Serbsky National Medical Research Center of Psychiatry and Narcology of the RF Ministry of Public Health, Moscow, Russia.
O I GurinaDepartment of Basic and Applied Neurobiology, Serbsky National Medical Research Center of Psychiatry and Narcology of the RF Ministry of Public Health, Moscow, Russia.
K Sh TarkovskayaDepartment of Basic and Applied Neurobiology, Serbsky National Medical Research Center of Psychiatry and Narcology of the RF Ministry of Public Health, Moscow, Russia.
A N InozemtsevDepartment of Higher Nervous Function, Moscow State University, Moscow, Russia.
V P ChekhoninDepartment of Basic and Applied Neurobiology, Serbsky National Medical Research Center of Psychiatry and Narcology of the RF Ministry of Public Health, Moscow, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Electroconvulsive therapy (ECT) is an effective treatment method for depression therapy. It produces a number of biological effects, including neurotrophic factors regulation. In the present paper, we investigated the ECT response in depressed rats subjected to the variable frequency ultrasound (20-45 kHz) and examined the contribution of brain-derived neurotrophic factor (BDNF) expression changes to the observed effects. The obtained results reflect the therapeutic potential of ECT for the treatment of depressive-like state in rodents and indicate the role of BDNF in these processes. In future research, it is necessary to investigate the relationship between neurotrophin and structural changes and to study other neurotrophic biomarkers that may be associated with the development of depression-like state and the therapy response.

Indexed as

Brain-Derived Neurotrophic FactorDepressionElectroconvulsive TherapyAnimalsMaleRatsRats, WistarBdnf protein, ratBrain-Derived Neurotrophic FactorBDNFdepressionelectroconvulsive therapyratsultrasound

Identifiers

PMID39400901

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.