Evidence map›Paper›PMID 39401577›Full record

ArticleJournal of stroke and cerebrovascular diseases : the official journal of National Stroke Association2024

Age differences in the change in cognition after stroke.

Mellanie V Springer, Bingxin Chen, Rachael T Whitney, Emily M Briceño, Alden L Gross, Hugo J Aparicio, Alexa S Beiser, James F Burke, Bruno Giordani, Rebecca F Gottesman and 7 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Mellanie V SpringerDepartment of Neurology and Stroke Program, University of Michigan, Ann Arbor, MI, USA; Institute for Healthcare Policy and Innovation, University of Michigan, Ann Arbor, MI, USA. Electronic address: mvsprin@med.umich.edu.
Bingxin ChenDepartment of Nursing, University of Michigan, Ann Arbor, MI, USA.
Rachael T WhitneyDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Emily M BriceñoCognitive Health Services Research Program, University of Michigan, Ann Arbor, MI, USA; Department of Physical Medicine and Rehabilitation, University of Michigan, Ann Arbor, MI, USA.
Alden L GrossDepartment of Epidemiology, Johns Hopkins Bloomberg School Public Health, Baltimore, MD, USA.
Hugo J AparicioDepartment of Neurology, Boston University School of Medicine, Boston, MA, USA; Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, MA, USA.
Alexa S BeiserDepartment of Neurology, Boston University School of Medicine, Boston, MA, USA; Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, MA, USA; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
James F BurkeDepartment of Neurology, Ohio State University College of Medicine, Columbus, OH, USA.
Bruno GiordaniDepartment of Psychiatry and Michigan Alzheimer's Disease Center, University of Michigan, Ann Arbor, MI, USA.
Rebecca F GottesmanStroke Branch, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.
Rodney A HaywardInstitute for Healthcare Policy and Innovation, University of Michigan, Ann Arbor, MI, USA; Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA; Cognitive Health Services Research Program, University of Michigan, Ann Arbor, MI, USA; VA Ann Arbor Healthcare System, Ann Arbor, MI, USA.
Virginia J HowardDepartment of Epidemiology, University of Alabama at Birmingham School of Public Health, Birmingham, AL, USA.
Silvia KotonDepartment of Epidemiology, Johns Hopkins Bloomberg School Public Health, Baltimore, MD, USA; Department of Nursing, The Stanley Steyer School of Health Professions, Tel Aviv University, Tel Aviv, Israel.
Ronald M LazarDepartment of Neurology and Evelyn F. McKnight Brain Institute, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Jeremy B SussmanInstitute for Healthcare Policy and Innovation, University of Michigan, Ann Arbor, MI, USA; Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA; Cognitive Health Services Research Program, University of Michigan, Ann Arbor, MI, USA; VA Ann Arbor Healthcare System, Ann Arbor, MI, USA.
Wen YeDepartment of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Deborah A LevineDepartment of Neurology and Stroke Program, University of Michigan, Ann Arbor, MI, USA; Institute for Healthcare Policy and Innovation, University of Michigan, Ann Arbor, MI, USA; Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA; Cognitive Health Services Research Program, University of Michigan, Ann Arbor, MI, USA.

Funding

The Effect of Vascular Risk Factors on Risk of Alzheimer's Disease and Related Dementias after Stroke (STROKE COG)RF1AG068410 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LEVINE, DEBORAH ALLISON · 2020 to 2020
$3.1M
Measurement of cognition and functional decline in Latinx older adults for detection of Alzheimer’s Disease and Related Dementias: A mixed-methods approachK23AG080035 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Emily Marie Briceno · 2023 to 2026
$767k
NIA NIH HHS K23 AG080035NIA NIH HHS RF1 AG068410
6 · The paper itself

Abstract

objectiveTo compare changes in cognitive trajectories after stroke between younger (18-64) and older (65+) adults, accounting for pre-stroke cognitive trajectories. MATERIALS AND

methodsPooled cohort study using individual participant data from 3 US cohorts (1971-2019), the Atherosclerosis Risk In Communities Study (ARIC), Framingham Offspring Study (FOS), and REasons for Geographic And Racial Differences in Stroke Study (REGARDS). Linear mixed effect models evaluated the association between age and the initial change (intercept) and rate of change (slope) in cognition after compared to before stroke. Outcomes were global cognition (primary), memory and executive function.

resultsWe included 1,292 participants with stroke; 197 younger (47.2 % female, 32.5 % Black race) and 1,095 older (50.2 % female, 46.4 % Black race). Median (IQR) age at stroke was 59.7 (56.6-61.7) (younger group) and 75.2 (70.5-80.2) years (older group). Compared to the young, older participants had greater declines in global cognition (-1.69 point [95 % CI, -2.82 to -0.55] greater), memory (-1.05 point [95 % CI, -1.92 to -0.17] greater), and executive function (-3.72 point [95 % CI, -5.23 to -2.21] greater) initially after stroke. Older age was associated with faster declines in global cognition (-0.18 points per year [95 % CI, -0.36 to -0.01] faster) and executive function (-0.16 [95 % CI, -0.26 to -0.06] points per year for every 10 years of higher age), but not memory (-0.006 [95 % CI, -0.15 to 0.14]), after compared to before stroke.

conclusionOlder age was associated with greater post-stroke cognitive declines, accounting for differences in pre-stroke cognitive trajectories between the old and the young.

Indexed as

CognitionExecutive FunctionMemoryStrokeAdolescentAdultAgedAged, 80 and overAge FactorsCognitive DysfunctionDisease ProgressionFemaleHumansMaleMiddle AgedPrognosisAgingCognitionCognitive declineHemorrhagic strokeIschemic strokeStroke

Identifiers

PMID39401577
PMCPMC11906114

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.