ArticleNature immunology2024
Inflammasome protein scaffolds the DNA damage complex during tumor development.
Abstract read
In one paragraph
Article in Nature immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Matrine Suppresses Lung Cancer Progression via Dual Inhibition of CHEK1-Mediated DNA Damage Repair and PI3K/AKT Survival Signaling.Thoracic cancer · 2026Article
- Article
- Current understanding of the NLRC4 Inflammasome in autoinflammation and enterocolitis.Communications biology · 2026Review
- Obesity-associated inflammation and cancer: molecular mechanisms, evidence gaps, and therapeutic opportunities.Frontiers in immunology · 2026Review
- Molecular mechanisms and regulation of inflammasome activation and signaling: sensing of pathogens and damage molecular patterns.Cellular & molecular immunology · 2025Review
- The inflammasome sensor NLRP3 interacts with REV7 to maintain genome integrity through homologous recombination.Nucleic acids research · 2025Article
- tRF3a-MetCAT Promotes EGFR-Targeted Therapeutic Resistance through the TRIM21-STAT1-C5a Axis in Lung Adenocarcinoma.Research (Washington, D.C.) · 2025Article
- A stromal inflammasome Ras safeguard against Myc-driven lymphomagenesis.Nature immunology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
25 authors.
Cheng ShenDivision of Immunology and Infectious Diseases, The John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia.ORCID http://orcid.org/0000-0002-6098-1205
Abhimanu PandeyDivision of Immunology and Infectious Diseases, The John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia.ORCID http://orcid.org/0000-0002-2367-3422
Daniel Enosi TuipulotuDivision of Immunology and Infectious Diseases, The John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia.ORCID http://orcid.org/0000-0002-6442-4633
Anukriti MathurDivision of Immunology and Infectious Diseases, The John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia.
Lixinyu LiuDivision of Genome Sciences and Cancer, The John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia.
Haoyu YangDivision of Genome Sciences and Cancer, The John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia.
Nilanthi K AdikariDivision of Immunology and Infectious Diseases, The John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia.
Chinh NgoDivision of Immunology and Infectious Diseases, The John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia.
Weidong JingDivision of Immunology and Infectious Diseases, The John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia.
Shouya FengDivision of Immunology and Infectious Diseases, The John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia.
Yuwei HaoDivision of Immunology and Infectious Diseases, The John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia.ORCID http://orcid.org/0000-0003-3932-3686
Anyang ZhaoDivision of Immunology and Infectious Diseases, The John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia.
Max KirkbyDivision of Immunology and Infectious Diseases, The John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia.
Melan KureraDivision of Immunology and Infectious Diseases, The John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia.
Jing ZhangDivision of Immunology and Infectious Diseases, The John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia.
Shweta VenkataramanDivision of Immunology and Infectious Diseases, The John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia.
Cheng LiuConjoint Gastroenterology Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.
Renhua SongEpigenetics and RNA Biology Laboratory, The School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Camperdown, New South Wales, Australia.
Justin J-L WongEpigenetics and RNA Biology Laboratory, The School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Camperdown, New South Wales, Australia.ORCID http://orcid.org/0000-0002-7038-5079
Ulrike SchumannThe John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia.
Riccardo NatoliThe John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia.
Jiayu WenDivision of Genome Sciences and Cancer, The John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia.
Liman ZhangDepartment of Chemical Physiology and Biochemistry, Oregon Health and Science University, Portland, OR, USA.
Nadeem O KaakoushSchool of Biomedical Sciences, University of New South Wales Sydney, Sydney, New South Wales, Australia.ORCID http://orcid.org/0000-0003-4017-1077
Si Ming ManDivision of Immunology and Infectious Diseases, The John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia. siming.man@anu.edu.au.ORCID http://orcid.org/0000-0002-5079-2857
Funding
Elucidating the Structural Mechanisms of NAIP Receptors in Bacterial Detection and Inflammasome ActivationR01AI165580 · NIAID · VAN ANDEL RESEARCH INSTITUTE · PI Liman Zhang · 2022 to 2026
$2.1MCancer Council ACT Cancer Council ACT Research GrantDepartment of Health | National Health and Medical Research Council (NHMRC) 2026910Department of Health | National Health and Medical Research Council (NHMRC) APP2002686Gastroenterological Society of Australia (GESA) Gastroenterological Society of Australia GESA Mostyn Family GrantNIAID NIH HHS R01 AI165580
Abstract
Inflammasome sensors activate cellular signaling machineries to drive inflammation and cell death processes. Inflammasomes also control the development of certain diseases independently of canonical functions. Here, we show that the inflammasome protein NLR family CARD domain-containing protein 4 (NLRC4) attenuated the development of tumors in the Apc
Indexed as
Apoptosis Regulatory ProteinsCalcium-Binding ProteinsCheckpoint Kinase 1DNA DamageInflammasomesAdaptor Proteins, Signal TransducingAnimalsCARD Signaling Adaptor ProteinsHumansMiceMice, Inbred C57BLMice, KnockoutNeoplasmsSignal TransductionAdaptor Proteins, Signal TransducingApoptosis Regulatory ProteinsCalcium-Binding ProteinsCARD Signaling Adaptor ProteinsCheckpoint Kinase 1Chek1 protein, mouseInflammasomesIpaf protein, mouse
Identifiers
PMID
39402152What Socratic holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.