ArticleNature neuroscience2024
Integrated multimodal cell atlas of Alzheimer's disease.
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In one paragraph
Article in Nature neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 260 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
260citing papers in PubMed, 2 pooled it
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
260 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The role of AI-assisted drug repurposing in neurological disorders: a systematic review of validation strategies, challenges and opportunities.Journal of nanobiotechnology · 2026Pooled it
- A meta-analysis of single-nucleus expression quantitative trait loci linking genetic risk to brain disorders.Nature genetics · 2026Pooled it
- Integrating network medicine and foundation models reveals cell-type-specific regulatory alterations in Alzheimer's disease.NAR genomics and bioinformatics · 2026Article
- Hippocampal inflammasome enrichment in intermediate Alzheimer's disease: Strong spatial findings, but clearer stage and mechanistic definition are needed.Brain pathology (Zurich, Switzerland) · 2026Article
- The misplaced mouse Pax6 interneuron subclass: A cross-species transcriptomic reassignment.iScience · 2026Article
- Accurate and well-powered case-control analysis of spatial molecular data.Nature methods · 2026Article
- Collagen Triple Helix Repeat Containing 1 (CTHRC1) in the Nervous System: Expression, Signaling Mechanisms, and Functional Implications.Journal of molecular neuroscience : MN · 2026Review
- Review
- Article
- Personalized single-cell transcriptomics reveals molecular diversity in Alzheimer's disease.Nature communications · 2026Article
- ABCC9/SUR2 has a Complex Expression Pattern in Human Brain Gliovascular Unit Cells, Including Astrocytes.Journal of molecular neuroscience : MN · 2026Article
- The TyrRS cascade: circadian gating of neuronal DNA repair and its collapse in aging.GeroScience · 2026Review
- Distinct cellular phenotypes of language and executive decline in amyotrophic lateral sclerosis.Cell · 2026Article
- Temporal transcriptomic remodeling after controlled cortical impact reveals delayed AQP4/SNTA1 expression imbalance associated with ion-homeostatic remodeling.bioRxiv : the preprint server for biology · 2026Article
- LIGER2: Scalable Single-Cell Integration with On-Disk Datasets.bioRxiv : the preprint server for biology · 2026Article
- Dysregulated TIE-2 expression in Alzheimer's disease: Further considerations on regional specificity and shedding evidence.Brain pathology (Zurich, Switzerland) · 2026Article
- Article
- A meta-refined human Alzheimer's disease-associated gene subset shows partial mouse-model pathway correspondence and limited cross-cohort machine-learning transportability.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Reduced expression of Brain Expressed X-linked genes in Alzheimer's disease.Journal of Alzheimer's disease : JAD · 2026Article
- Solute carrier membrane transporters: emerging targets in CNS disorders.Nature reviews. Drug discovery · 2026Review
200 more citing papers are in PubMed but not listed here.
Corrections and comments
- Update of
Authors and funding
108 authors.
Mariano I Gabitto *Allen Institute for Brain Science, Seattle, WA, USA.
Kyle J Travaglini *Allen Institute for Brain Science, Seattle, WA, USA.ORCID http://orcid.org/0000-0003-3164-6448
Victoria M RachleffAllen Institute for Brain Science, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-5003-508X
Eitan S KaplanAllen Institute for Brain Science, Seattle, WA, USA.
Brian LongAllen Institute for Brain Science, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-7793-5969
Jeanelle ArizaAllen Institute for Brain Science, Seattle, WA, USA.
Yi DingAllen Institute for Brain Science, Seattle, WA, USA.
Joseph T MahoneyAllen Institute for Brain Science, Seattle, WA, USA.
Nick DeeAllen Institute for Brain Science, Seattle, WA, USA.
Jeff GoldyAllen Institute for Brain Science, Seattle, WA, USA.
Erica J MeliefDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.
Anamika AgrawalCenter for Data-Driven Discovery for Biology, Allen Institute, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-1213-2321
Omar KanaAllen Institute for Brain Science, Seattle, WA, USA.
Xingjian ZhenAllen Institute for Brain Science, Seattle, WA, USA.
Samuel T BarlowAllen Institute for Brain Science, Seattle, WA, USA.
Krissy BrounerAllen Institute for Brain Science, Seattle, WA, USA.
Jazmin CamposAllen Institute for Brain Science, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-9384-9913
John CamposDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.
Ambrose J CarrChan Zuckerberg Initiative, Redwood City, CA, USA.
Tamara CasperAllen Institute for Brain Science, Seattle, WA, USA.
Rushil ChakrabartyAllen Institute for Brain Science, Seattle, WA, USA.ORCID http://orcid.org/0000-0003-1722-8557
Michael ClarkAllen Institute for Brain Science, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-8006-4332
Jonah CoolChan Zuckerberg Initiative, Redwood City, CA, USA.
Rachel DalleyAllen Institute for Brain Science, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-7461-7845
Martin DarvasDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.
Song-Lin DingAllen Institute for Brain Science, Seattle, WA, USA.
Tim DolbeareAllen Institute for Brain Science, Seattle, WA, USA.
Tom EgdorfAllen Institute for Brain Science, Seattle, WA, USA.
Luke EspositoAllen Institute for Brain Science, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-3565-9126
Rebecca FerrerAllen Institute for Brain Science, Seattle, WA, USA.
Lynn E FleckensteinKaiser Permanente Washington Health Research Institute, Seattle, WA, USA.ORCID http://orcid.org/0009-0008-9533-7015
Rohan GalaAllen Institute for Brain Science, Seattle, WA, USA.ORCID http://orcid.org/0000-0003-1872-0957
Amanda GaryAllen Institute for Brain Science, Seattle, WA, USA.
Emily GelfandAllen Institute for Brain Science, Seattle, WA, USA.ORCID http://orcid.org/0000-0003-2175-5894
Jessica GloeAllen Institute for Brain Science, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-8343-3423
Nathan GuilfordAllen Institute for Brain Science, Seattle, WA, USA.
Junitta GuzmanAllen Institute for Brain Science, Seattle, WA, USA.
Daniel HirschsteinAllen Institute for Brain Science, Seattle, WA, USA.
Windy HoAllen Institute for Brain Science, Seattle, WA, USA.
Madison HuppAllen Institute for Brain Science, Seattle, WA, USA.
Tim JarskyAllen Institute for Brain Science, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-4399-539X
Nelson JohansenAllen Institute for Brain Science, Seattle, WA, USA.
Brian E KalmbachAllen Institute for Brain Science, Seattle, WA, USA.ORCID http://orcid.org/0000-0003-3136-8097
Lisa M KeeneDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.
Sarah KhawandDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.
Mitchell D KilgoreDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0003-1101-6924
Amanda KirklandDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.
Michael KunstAllen Institute for Brain Science, Seattle, WA, USA.
Brian R LeeAllen Institute for Brain Science, Seattle, WA, USA.
Mckaila LeytzeAllen Institute for Brain Science, Seattle, WA, USA.
Christine L Mac DonaldDepartment of Neurological Surgery, University of Washington, Seattle, WA, USA.
Jocelin MaloneAllen Institute for Brain Science, Seattle, WA, USA.ORCID http://orcid.org/0000-0003-0794-4250
Zoe MaltzerAllen Institute for Brain Science, Seattle, WA, USA.
Naomi MartinAllen Institute for Brain Science, Seattle, WA, USA.
Rachel McCueAllen Institute for Brain Science, Seattle, WA, USA.
Delissa McMillenAllen Institute for Brain Science, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-3413-4424
Gonzalo MenaDepartment of Statistics and Data Science, Carnegie Mellon University, Pittsburgh, PA, USA.
Emma MeyerdierksAllen Institute for Brain Science, Seattle, WA, USA.
Kelly P MeyersKaiser Permanente Washington Health Research Institute, Seattle, WA, USA.
Tyler MollenkopfAllen Institute for Brain Science, Seattle, WA, USA.
Mark MontineDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.
Amber L NolanDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.
Julie K NyhusAllen Institute for Brain Science, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-2006-8235
Paul A OlsenAllen Institute for Brain Science, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-8132-3722
Maiya PaclebDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0009-0000-0242-2475
Chelsea M PaganAllen Institute for Brain Science, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-3932-9992
Nicholas PeñaAllen Institute for Brain Science, Seattle, WA, USA.
Trangthanh PhamAllen Institute for Brain Science, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-4738-5062
Christina Alice PomAllen Institute for Brain Science, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-9057-040X
Nadia PostupnaDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-4939-4915
Christine RimorinAllen Institute for Brain Science, Seattle, WA, USA.
Augustin RuizAllen Institute for Brain Science, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-8361-5152
Giuseppe A SaldiAllen Institute for Brain Science, Seattle, WA, USA.
Aimee M SchantzDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0009-0006-2634-4970
Nadiya V ShapovalovaAllen Institute for Brain Science, Seattle, WA, USA.
Staci A SorensenAllen Institute for Brain Science, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-6799-2126
Brian StaatsAllen Institute for Brain Science, Seattle, WA, USA.
Matt SullivanAllen Institute for Brain Science, Seattle, WA, USA.
Susan M SunkinAllen Institute for Brain Science, Seattle, WA, USA.
Carol ThompsonAllen Institute for Brain Science, Seattle, WA, USA.
Michael TieuAllen Institute for Brain Science, Seattle, WA, USA.
Jonathan T TingAllen Institute for Brain Science, Seattle, WA, USA.
Amy TorkelsonAllen Institute for Brain Science, Seattle, WA, USA.
Tracy TranAllen Institute for Brain Science, Seattle, WA, USA.
Nasmil J Valera CuevasAllen Institute for Brain Science, Seattle, WA, USA.
Sarah Walling-BellAllen Institute for Brain Science, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-6995-2681
Ming-Qiang WangAllen Institute for Brain Science, Seattle, WA, USA.
Jack WatersAllen Institute for Brain Science, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-2312-4183
Angela M WilsonDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.
Ming XiaoDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.
David HaynorDepartment of Radiology, University of Washington, Seattle, WA, USA.
Nicole M GattoKaiser Permanente Washington Health Research Institute, Seattle, WA, USA.
Suman JayadevDepartment of Neurology, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0003-3164-9665
Shoaib MuftiAllen Institute for Brain Science, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-8173-3884
Lydia NgAllen Institute for Brain Science, Seattle, WA, USA.
Shubhabrata MukherjeeDepartment of Medicine, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0003-2522-2884
Paul K CraneDepartment of Medicine, University of Washington, Seattle, WA, USA.
Caitlin S LatimerDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.
Boaz P LeviAllen Institute for Brain Science, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-8346-872X
Kimberly A SmithAllen Institute for Brain Science, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-3142-1970
Jennie L CloseAllen Institute for Brain Science, Seattle, WA, USA.
Jeremy A MillerAllen Institute for Brain Science, Seattle, WA, USA.ORCID http://orcid.org/0000-0003-4549-588X
Rebecca D HodgeAllen Institute for Brain Science, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-5784-9668
Eric B LarsonDepartment of Medicine, University of Washington, Seattle, WA, USA.
Thomas J GrabowskiDepartment of Radiology, University of Washington, Seattle, WA, USA.
Michael HawrylyczAllen Institute for Brain Science, Seattle, WA, USA. mikeh@alleninstitute.org.ORCID http://orcid.org/0000-0002-5741-8024
C Dirk KeeneDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA. cdkeene@uw.edu.ORCID http://orcid.org/0000-0002-5291-1469
Ed S LeinAllen Institute for Brain Science, Seattle, WA, USA. edl@alleninstitute.org.ORCID http://orcid.org/0000-0001-9012-6552
Funding
Functionally guided adult whole brain cell atlas in human and NHPUM1MH130981 · NIMH · ALLEN INSTITUTE · PI Ed Lein, Hongkui Zeng · 2022 to 2026
$91.9MTopographic, cell type and molecular pathway characterization ofAlzheimer's disease using single cell transcriptomics and epigenomicsU19AG060909 · NIA · ALLEN INSTITUTE · PI Ed Lein · 2020 to 2026
$83.6MTranslational pharmacoepidemiology: neuroprotection and neurotoxicity of antihypertensives and strong anticholinergicsU19AG066567 · NIA · KAISER FOUNDATION RESEARCH INSTITUTE · PI Christine L MacDonald · 2021 to 2026
$80.4MAlzheimer's Disease Genetics ConsortiumU01AG032984 · NIA · UNIVERSITY OF PENNSYLVANIA · PI SCHELLENBERG, GERARD DAVID · 2009 to 2024
$60.4MTHERAPEUTIC EFFECTS OF INTRA-NASAL INSULIN DETEMIRP50AG005136 · NIA · UNIVERSITY OF WASHINGTON · PI GRABOWSKI, THOMAS J. · 1985 to 2019
$57.2MSUPPLEMENT TO RUSH ALZHEIMERS DISEASE CENTER COREP30AG010161 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 1991 to 2020
$49.1MEPIDEMIOLOGY OF NEURAL RESERVE AND NEUROBIOLOGY IN AGINGR01AG017917 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 2001 to 2023
$43.3MAging eyes and aging brains in studying alzheimer's disease: Modern ophthalmic data collection in the adult changes in thought (ACT) studyR01AG060942 · NIA · WASHINGTON UNIVERSITY · PI Cecilia Sungmin Lee · 2019 to 2026
$39.4MFurthering scientific understanding of mechanisms underlying resilience to the effects of AD pathology by incorporating state of the art quantification of gliosis, inflammation, & synaptic toxicityU01AG006781 · NIA · UNIVERSITY OF WASHINGTON · PI CRANE, PAUL K, LARSON, ERIC B · 1986 to 2020
$39.3MUniversity of Washington Alzheimer's Disease Research CenterP30AG066509 · NIA · UNIVERSITY OF WASHINGTON · PI Amanda D. Boyd · 2020 to 2026
$29.0MRush Alzheimer's Disease Research CenterP30AG072975 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI Lisa L Barnes, Julie A. Schneider · 2021 to 2026
$24.7MRISK FACTORS, PATHOLOGY, AND CLINICAL EXPRESSIONS OF ADR01AG015819 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 1998 to 2024
$21.4MNHGRI NIH HHS R01 HG008155NIA NIH HHS P30 AG010161NIA NIH HHS P30 AG066509NIA NIH HHS P30 AG072975NIA NIH HHS P50 AG005136NIA NIH HHS R01 AG015819NIA NIH HHS R01 AG017917NIA NIH HHS R01 AG030146NIA NIH HHS R01 AG036042NIA NIH HHS R01 AG036836NIA NIH HHS R01 AG048015NIA NIH HHS R01 AG058002NIA NIH HHS R01 AG060942NIA NIH HHS R01 AG062335NIA NIH HHS R01 AG065406NIA NIH HHS R01 AG066831NIA NIH HHS R01 AG074003NIA NIH HHS RC2 AG036547NIA NIH HHS RF1 AG054012NIA NIH HHS RF1 AG054321NIA NIH HHS RF1 AG057473NIA NIH HHS RF1 AG062377NIA NIH HHS RF1 AG065406NIA NIH HHS U01 AG006781NIA NIH HHS U01 AG032984NIA NIH HHS U01 AG046152NIA NIH HHS U01 AG046161NIA NIH HHS U01 AG061356NIA NIH HHS U01 AG072572NIA NIH HHS U19 AG060909NIA NIH HHS U19 AG066567NIA NIH HHS U24 AG072458NIGMS NIH HHS T32 GM087237NIMH NIH HHS U01 MH119509NIMH NIH HHS UM1 MH130981NINDS NIH HHS R01 NS105984NINDS NIH HHS R01 NS127187NINDS NIH HHS U01 NS110453NINDS NIH HHS U24 NS133945NINDS NIH HHS U24 NS133949NINDS NIH HHS U24 NS135561NINDS NIH HHS UG3 NS115064NINDS NIH HHS UH3 NS115064U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) P30AG066509U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) P50AG005136U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) U01AG006781U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) U19AG060909U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) U19AG066567
Abstract
Alzheimer's disease (AD) is the leading cause of dementia in older adults. Although AD progression is characterized by stereotyped accumulation of proteinopathies, the affected cellular populations remain understudied. Here we use multiomics, spatial genomics and reference atlases from the BRAIN Initiative to study middle temporal gyrus cell types in 84 donors with varying AD pathologies. This cohort includes 33 male donors and 51 female donors, with an average age at time of death of 88 years. We used quantitative neuropathology to place donors along a disease pseudoprogression score. Pseudoprogression analysis revealed two disease phases: an early phase with a slow increase in pathology, presence of inflammatory microglia, reactive astrocytes, loss of somatostatin
Indexed as
Alzheimer DiseaseNeuronsAgedAged, 80 and overAstrocytesAtlases as TopicDisease ProgressionFemaleHumansMaleMicrogliaTemporal Lobe
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.