Evidence map›Paper›PMID 39402462›Full record

ArticleBMC cancer2024

Ethoxy-erianin phosphate inhibits angiogenesis in colorectal cancer by regulating the TMPO-AS1/miR-126-3p/PIK3R2 axis and inactivating the PI3k/AKT signaling pathway.

Shaoqun Liu, Fei Teng, Yuxin Lu, Yanqing Zhu, Xin Liang, Fanhong Wu, Jianwen Liu, Wenming Zhou, Chang Su, Yiou Cao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shaoqun Liu *Department of Gastrointestinal Surgery, Minhang Hospital, Fudan University, Shanghai, China.
Fei Teng *Department of Gastrointestinal Surgery, Minhang Hospital, Fudan University, Shanghai, China.
Yuxin Lu *Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai, China.
Yanqing ZhuShanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai, China.
Xin LiangShanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai, China.
Fanhong WuSchool of Chemical and Environmental Engineering, Shanghai Institute of Technology, Shanghai, China.
Jianwen LiuShanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai, China.
Wenming ZhouDepartment of Endoscope Center, Minhang Hospital, Fudan University, Shanghai, China. 23099145@qq.com.
Chang SuDepartment of Gastrointestinal Surgery, Minhang Hospital, Fudan University, Shanghai, China. suchang_jx@126.com.
Yiou CaoDepartment of Gastrointestinal Surgery, Minhang Hospital, Fudan University, Shanghai, China. yioucao_doctor@126.com.

Funding

Fundamental Medical Project of Minhang Hospital of Fudan University Project Foundation 2022MHBJ03Shanghai Minhang District high level specialist doctor training program 2020MZYS15Shanghai Minhang District large-scale discipline construction project 2017MWDXK03Shanghai Minhang Science and Technology Commission 2023MHZ072
6 · The paper itself

Abstract

Colorectal cancer (CRC) is the third most common malignancy, with increasing prevalence and mortality. How the ethoxy-erianin phosphate (EBTP) mediates CRC development remains unclear. Therefore, the current study evaluated the effects of EBTP on the proliferation, migration, and angiogenesis of CRC cells using CCK-8, Wound-healing, Transwell, and Tube formation assays. RNA sequencing and molecular docking techniques helped predict that EBTP could inhibit angiogenesis by regulating PIK3R2 expression while clarifying the mechanism behind EBTP-mediated CRC angiogenesis. Subsequently, several in vitro experiments indicated that PIK3R2 overexpression significantly improved the proliferation, migration, and angiogenesis of CRC cells while knocking down PIK3R2 expression inhibited their proliferation, migration, and angiogenesis. Simultaneously, PIK3R2 expression in CRC cells gradually decreased with increased EBTP concentration and action duration. Moreover, PIK3R2 overexpression in CRC cells could reverse the inhibitory EBTP effect in angiogenesis. Mouse experiments also depicted that EBTP inhibited CRC angiogenesis by down-regulating PIK3R2 expression. In addition, EBTP could inhibit PI3K/AKT pathway activity and indirectly control PIK3R2 expression through the lncRNA TMPO-AS1/miR-126-3p axis. Our findings highlighted that EBTP could inhibit CRC angiogenesis using the TMPO-AS1/miR-126-3p/PIK3R2/PI3k/AKT axis, providing a novel strategy for anti-angiogenic therapy in CRC.

Indexed as

Cell ProliferationColorectal NeoplasmsMicroRNAsNeovascularization, PathologicPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktSignal TransductionAngiogenesisAnimalsCell Line, TumorCell MovementGene Expression Regulation, NeoplasticHumansMiceMice, NudeRNA, Long NoncodingMicroRNAsMIRN126 microRNA, humanPhosphatidylinositol 3-Kinasesphosphoinositol-3 kinase regulatory subunit 2, humanProto-Oncogene Proteins c-aktRNA, Long NoncodingAngiogenesisColorectal cancerEBTPPIK3R2TMPO-AS1

Identifiers

PMID39402462
PMCPMC11476319

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.