Evidence map›Paper›PMID 39402808›Full record

ArticleJournal of cellular physiology2025

Leukotriene B4 is elevated in diabetes and promotes ventricular arrhythmogenesis in guinea pig.

Andrea Corbin, Kelly A Aromolaran, Ademuyiwa S Aromolaran

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Article in Journal of cellular physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Andrea CorbinNora Eccles Harrison Cardiovascular Research and Training Institute (CVRTI), University of Utah School of Medicine, Salt Lake City, Utah, USA.
Kelly A AromolaranNora Eccles Harrison Cardiovascular Research and Training Institute (CVRTI), University of Utah School of Medicine, Salt Lake City, Utah, USA.
Ademuyiwa S AromolaranNora Eccles Harrison Cardiovascular Research and Training Institute (CVRTI), University of Utah School of Medicine, Salt Lake City, Utah, USA.ORCID 0000-0002-3114-2939

Funding

Leukotriene B4 Regulation in HeartR01HL174450 · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · 2025 to 2025
$616k
NHLBI NIH HHS R01 HL147044NHLBI NIH HHS R01 HL147044-01NHLBI NIH HHS R01 HL174450NHLBI NIH HHS R01 HL174450-01
6 · The paper itself

Abstract

Diabetes (DM) patients have an increased risk (~50%) for sudden cardiac death (SCD), mostly as a result of ventricular arrhythmias. The molecular mechanisms involved remain partially defined. The potent proinflammatory lipid mediator leukotriene (LT) B4, is pathologically elevated in DM compared to nondiabetic patients, resulting in increased LTB4 accumulation in heart, leading to an increased risk for life-threatening proarrhythmic signatures. We used electrophysiology, immunofluorescence, and confocal microscopy approaches to evaluate LTB4 cellular effects in guinea pig heart and ventricular myocytes. We have observed that LTB4 is increased in multiple mouse models (C57BL/6 J/Lep

Indexed as

Arrhythmias, CardiacDiabetes MellitusDiabetes Mellitus, ExperimentalLeukotriene B4Action PotentialsAnimalsGuinea PigsHeart VentriclesHEK293 CellsHumansMaleMiceMice, Inbred C57BLMyocytes, CardiacReceptors, Leukotriene B4Leukotriene B4Receptors, Leukotriene B4diabetesguinea pighERGIKrleukotriene B4ventricular arrhythmias

Identifiers

PMID39402808
PMCPMC11733858

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.