Evidence map›Paper›PMID 39403060›Full record

ArticleCurrent neuropharmacology2024

Reduced Serum Brain-Derived Neurotrophic Factor in Infants Affected by Severe Bronchiolitis.

Raffaella Nenna, Carla Petrella, Enea Bonci, Paola Papoff, Margherita di Jorgi, Laura Petrarca, Maria Giulia Conti, Christian Barbato, Alessandra Pietrangeli, Marco Fiore and 2 more

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In one paragraph

Article in Current neuropharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Raffaella NennaDepartment of Experimental Medicine, Medical Faculty, Sapienza University of Rome, Italy.
Carla PetrellaDepartment of Sense Organs, Medical Faculty, Institute of Biochemistry and Cell Biology (IBBC-CNR), Sapienza University of Rome, Viale del Policlinico 155-00161, Rome, Italy.
Enea BonciDepartment of Experimental Medicine, Medical Faculty, Sapienza University of Rome, Italy.
Paola PapoffDepartment of Experimental Medicine, Medical Faculty, Sapienza University of Rome, Italy.
Margherita di JorgiDepartment of Experimental Medicine, Medical Faculty, Sapienza University of Rome, Italy.
Laura PetrarcaDepartment of Experimental Medicine, Medical Faculty, Sapienza University of Rome, Italy.
Maria Giulia ContiDepartment of Experimental Medicine, Medical Faculty, Sapienza University of Rome, Italy.
Christian BarbatoDepartment of Sense Organs, Medical Faculty, Institute of Biochemistry and Cell Biology (IBBC-CNR), Sapienza University of Rome, Viale del Policlinico 155-00161, Rome, Italy.
Alessandra PietrangeliVirology Laboratory, Department of Molecular Medicine, "Sapienza" University, Rome, Italy.
Marco FioreDepartment of Sense Organs, Medical Faculty, Institute of Biochemistry and Cell Biology (IBBC-CNR), Sapienza University of Rome, Viale del Policlinico 155-00161, Rome, Italy.
Fabio MidullaDepartment of Maternal Infantile and Urological Sciences, Sapienza University of Rome, Viale Regina Elena 324-00161, Roma, Italy.
Brome GroupDepartment of Experimental Medicine, Medical Faculty, Sapienza University of Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBronchiolitis is an acute viral infection of the lower respiratory tract, typical of infants in their first year of life and causing hypoxia in the most serious cases. Bronchiolitis recognizes various demographic risk factors that are associated with greater clinical severity; however, no laboratory factors are yet able to correlate with the clinical severity. Neurotrophins as Brain-Derived Neurotrophic Factor (BDNF) are mediators of neuronal plasticity. BDNF is constitutively expressed in smooth muscle cells and epithelium of the lower respiratory tract, and as it is released during inflammatory conditions, serum levels may have a relevant role in the prognosis of infants with bronchiolitis.

objectiveIn the present pilot study, we aimed to disclose the presence of serum BDNF in infants hospitalized with bronchiolitis at discharge as a disease severity indicator. METHODS AND

resultsSerum BDNF, measured at hospital discharge, was significantly lower in severe bronchiolitis (expressed as O

conclusionLow serum BDNF in infants with severe bronchiolitis could be associated with a higher utilization by lung cells or with an altered production by lung cells. Therefore, further research is required to study if a decreased production or increased consumption of this biomarker is at the base of the above-mentioned findings.

Indexed as

Brain-Derived Neurotrophic FactorBronchiolitisBiomarkersFemaleHumansInfantMaleMembrane GlycoproteinsPilot ProjectsReceptor, trkBSeverity of Illness IndexBDNF protein, humanBiomarkersBrain-Derived Neurotrophic FactorMembrane GlycoproteinsReceptor, trkBtropomyosin-related kinase-B, humanBDNFbronchiolitisNeurotrophinNflO<sub>2</sub> supplementation.RSVTrkB

Identifiers

PMID39403060
PMCPMC11451311

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.